727686-80-8
727686-80-8
Chemical Structure
SKI-349
- CAS No.: 727686-80-8
- Formula:C19H19N3O4S
- Molecular Weight:385.44
InChIKey: OWBQCPZBRPKYKE-UHFFFAOYSA-N
SMILES: O=C(C1=C(N)N=C(NC2=CC=C(C=C2)OC)S1)C3=CC=C(C(OC)=C3)OC
Biological Activity: SKI-349 is a dual-targeted inhibitor of sphingosine kinase 1/2 (SPHK1/2) and microtubule assembly (MDA). SKI-349 has anticancer activity. SKI-349 can inhibit the vitality, invasion, and AKT/mTOR signaling pathway of liver cells[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SKI-349 | 99.55% | SKI-349 is a dual-targeted inhibitor of sphingosine kinase 1/2 (SPHK1/2) and microtubule assembly (MDA). SKI-349 has anticancer activity. SKI-349 can inhibit the vitality, invasion, and AKT/mTOR signaling pathway of liver cells. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.74
HY-113722DAT1 -
Similarity Score 0.65
HY-100950ABC1183 -
Similarity Score 0.63
HY-118447RO0505124 -
Similarity Score 0.60
HY-183854AG-12286 -
Similarity Score 0.59
HY-120744LDN-193665 -
Similarity Score 0.59
HY-119715AG-012986 -
Similarity Score 0.58
HY-182470AG-012986 dihydrochloride -
Similarity Score 0.57
HY-153343Veludacigib -
Similarity Score 0.57
HY-153343A(S)-Veludacigib -
Explore the MedChemAI to find more analogs
References
- [1]. Hengst JA, et al. Development of SKI-349, a dual-targeted inhibitor of sphingosine kinase and microtubule polymerization. Bioorg Med Chem Lett. 2020 Oct 15;30(20):127453. [Content Brief]
- [2]. Chen L, et al. SKI-349, a Sphingosine Kinases 1/2 Inhibitor, Suppresses Cell Viability, Invasion, and AKT/mTOR Signaling Pathway, and Shows Synergistic Cytotoxic Effects with Sorafenib in Hepatocellular Carcinoma. Tohoku J Exp Med. 2023 Dec 21. [Content Brief]
