DAT1

製品番号: HY-113722: Data Sheet 取扱説明書
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DAT1 is a potent antimitotic agent with anticancer effects. In HeLa cells, DAT1 blocks the spindle function by disturbing spindle microtubule and chromosome organization.

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DAT1 構造式

CAS 番号 : 107401-70-7

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製品説明

DAT1 is a potent antimitotic agent with anticancer effects. In HeLa cells, DAT1 blocks the spindle function by disturbing spindle microtubule and chromosome organization^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-CEM	IC₅₀	300 nM Compound: 5e	Antiproliferative activity against human CEM cells after 2 days by coulter counter method Antiproliferative activity against human CEM cells after 2 days by coulter counter method	[PMID: 19663386]
FM3A	IC₅₀	730 nM Compound: 5e	Antiproliferative activity against mouse FM3A cells after 2 days by coulter counter method Antiproliferative activity against mouse FM3A cells after 2 days by coulter counter method	[PMID: 19663386]
HeLa	IC₅₀	230 nM Compound: 5e	Antiproliferative activity against human HeLa cells after 2 days by coulter counter method Antiproliferative activity against human HeLa cells after 2 days by coulter counter method	[PMID: 19663386]
L1210	IC₅₀	850 nM Compound: 5e	Antiproliferative activity against mouse L1210 cells after 2 days by coulter counter method Antiproliferative activity against mouse L1210 cells after 2 days by coulter counter method	[PMID: 19663386]
MOLT-4	IC₅₀	230 nM Compound: 5e	Antiproliferative activity against human MOLT4 cells after 2 days by coulter counter method Antiproliferative activity against human MOLT4 cells after 2 days by coulter counter method	[PMID: 19663386]

体外実験

DAT1 shows cytotoxicity with GI₅₀ values ranging from 0.05 to 1 μM in different malignant cell lines (human tumour cells from cervix, colon and lung and mouse fibrosarcoma cells) with an average value of 0.35 μM. DAT1 blocks mitosis in the prometaphase and metaphase stages^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

325.38

分子式

C₁₇H₁₅N₃O₂S

CAS 番号

107401-70-7

SMILES

O=C(C1=C(N)N=C(NC2=CC=C(C=C2)OC)S1)C3=CC=CC=C3

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Suparna Sengupta, et al. 4-Amino-5-benzoyl-2-(4-methoxyphenylamino)thiazole (DAT1): a cytotoxic agent towards cancer cells and a probe for tubulin-microtubule system. Br J Pharmacol. 2005 Aug;145(8):1076-83. [Content Brief]

[2]. Nisha E Thomas, et al. Reversible action of diaminothiazoles in cancer cells is implicated by the induction of a fast conformational change of tubulin and suppression of microtubule dynamics. Mol Cancer Ther. 2014 Jan;13(1):179-89. [Content Brief]

DAT1 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DAT1107401-70-7DAT 1DAT-1Microtubule/Tubulinantimitotic agentanticancer effectsspindle microtubulechromosome organizationInhibitorinhibitorinhibit

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