DAT1
DAT1 is a potent antimitotic agent with anticancer effects. In HeLa cells, DAT1 blocks the spindle function by disturbing spindle microtubule and chromosome organization.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 107401-70-7
- Formule: C17H15N3O2S
- Masse moléculaire:325.38
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CCRF-CEM | IC50 |
300 nM
Compound: 5e
|
Antiproliferative activity against human CEM cells after 2 days by coulter counter method
Antiproliferative activity against human CEM cells after 2 days by coulter counter method
|
[PMID: 19663386] |
| FM3A | IC50 |
730 nM
Compound: 5e
|
Antiproliferative activity against mouse FM3A cells after 2 days by coulter counter method
Antiproliferative activity against mouse FM3A cells after 2 days by coulter counter method
|
[PMID: 19663386] |
| HeLa | IC50 |
230 nM
Compound: 5e
|
Antiproliferative activity against human HeLa cells after 2 days by coulter counter method
Antiproliferative activity against human HeLa cells after 2 days by coulter counter method
|
[PMID: 19663386] |
| L1210 | IC50 |
850 nM
Compound: 5e
|
Antiproliferative activity against mouse L1210 cells after 2 days by coulter counter method
Antiproliferative activity against mouse L1210 cells after 2 days by coulter counter method
|
[PMID: 19663386] |
| MOLT-4 | IC50 |
230 nM
Compound: 5e
|
Antiproliferative activity against human MOLT4 cells after 2 days by coulter counter method
Antiproliferative activity against human MOLT4 cells after 2 days by coulter counter method
|
[PMID: 19663386] |
DAT1 shows cytotoxicity with GI50 values ranging from 0.05 to 1 μM in different malignant cell lines (human tumour cells from cervix, colon and lung and mouse fibrosarcoma cells) with an average value of 0.35 μM. DAT1 blocks mitosis in the prometaphase and metaphase stages[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 107401-70-7
-
Masse moléculaire 325.38
-
Formule C17H15N3O2S
-
SMILES
O=C(C1=C(N)N=C(NC2=CC=C(C=C2)OC)S1)C3=CC=CC=C3
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Suparna Sengupta, et al. 4-Amino-5-benzoyl-2-(4-methoxyphenylamino)thiazole (DAT1): a cytotoxic agent towards cancer cells and a probe for tubulin-microtubule system. Br J Pharmacol. 2005 Aug;145(8):1076-83. [Content Brief]
[2]. Nisha E Thomas, et al. Reversible action of diaminothiazoles in cancer cells is implicated by the induction of a fast conformational change of tubulin and suppression of microtubule dynamics. Mol Cancer Ther. 2014 Jan;13(1):179-89. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DAT1 Related Classifications
HY-113722 Related Classifications
Powered by Bioz