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Art. -Nr.: HY-183854

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AG-12286

AG-12286 is a pan-CDK inhibitor with an IC₅₀ value of 2 nM against cdk1/cyclin B, 6 nM against cdk2/cyclin E, and 12 nM against cdk4/cyclin D. AG-12286 is 1000-fold more selective for the CDK family than for PKC. AG-12286 can be used in cancer research.

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CAS. Nr.: 223784-75-6
Formel: C₁₆H₁₂F₂N₄O₃S₂
Molecular Weight:410.42

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

AG-12286 Chemical Structure

CAS. Nr.: 223784-75-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Protokoll (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

Cdk1/cyclin B

2 nM (IC₅₀)

CDK2/cyclinE

6 nM (IC₅₀)

CDK4/cyclin D

12 nM (IC₅₀)

Alle CDK Isoform-spezifische Produkte anzeigen :

In Vitro

AG-12286 acts as a pan-cyclin-dependent kinase inhibitor, potently inhibiting cdk1/cycB (IC₅₀ = 2 nM), cdk2/cycE (IC₅₀ = 6 nM), and cdk4/cycD (IC₅₀ = 12 nM) while showing >1000X selectivity over PKC^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS. Nr. 223784-75-6
Molecular Weight 410.42
Formel C₁₆H₁₂F₂N₄O₃S₂
SMILES

O=C(C1=C(F)C=CC=C1F)C2=C(N)N=C(NC3=CC=C(S(=O)(N)=O)C=C3)S2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Kimball S D, et al. Cell cycle kinases and checkpoint regulation in cancer[J]. 2001.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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