223784-75-6
223784-75-6
Chemical Structure
AG-12286
- CAS No.: 223784-75-6
- Formula:C16H12F2N4O3S2
- Molecular Weight:410.42
InChIKey: BWWQFAUYHCRZKB-UHFFFAOYSA-N
SMILES: O=C(C1=C(F)C=CC=C1F)C2=C(N)N=C(NC3=CC=C(S(=O)(N)=O)C=C3)S2
Biological Activity: AG-12286 is a pan-CDK inhibitor with an IC50 value of 2 nM against cdk1/cyclin B, 6 nM against cdk2/cyclin E, and 12 nM against cdk4/cyclin D. AG-12286 is 1000-fold more selective for the CDK family than for PKC. AG-12286 can be used in cancer research[1].
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AG-12286 | AG-12286 is a pan-CDK inhibitor with an IC50 value of 2 nM against cdk1/cyclin B, 6 nM against cdk2/cyclin E, and 12 nM against cdk4/cyclin D. AG-12286 is 1000-fold more selective for the CDK family than for PKC. AG-12286 can be used in cancer research. | |||||||||||||||||||||
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References
Keywords
