1. Anti-infection
    Cell Cycle/DNA Damage
  2. CMV
    DNA/RNA Synthesis
  3. Braco-19

Braco-19 

Cat. No.: HY-15523
Handling Instructions

Braco-19 is a potent telomerase/telomere inhibitor and a HAdV virus replication inhibitor. BRACO-19 is a selective and high affinity G-quadruplex (GQ) binding ligand, stabilizing quadruplex formation at the 3V telomeric DNA overhang.

For research use only. We do not sell to patients.

Braco-19 Chemical Structure

Braco-19 Chemical Structure

CAS No. : 351351-75-2

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Description

Braco-19 is a potent telomerase/telomere inhibitor and a HAdV virus replication inhibitor. BRACO-19 is a selective and high affinity G-quadruplex (GQ) binding ligand, stabilizing quadruplex formation at the 3V telomeric DNA overhang[1][2].

IC50 & Target

IC50: G-quadruplex (GQ) binding ligand[1]

In Vitro

Braco-19, as a well-known GQ binding ligand, interacts specifically with the HAdV GQs and increases their stability, and blocks the HAdV multiplication[2].
BRACO-19 (1.0-10 μM; 5 day) cause zero growth inhibition is found 1 μM, the IC50 for BRACO-19 in UXF1138L cells is 2.5 μM, the IC100 is 5 μM[1].
BRACO-19 (1 μM; 24 hours) shows dramatically reduced nuclear hTERT expression. However, residual cytoplasmic hTERT staining is observed accompanied by the occurrence of atypical mitoses[1].
BRACO-19 (0-40 μM; 24 hours) decreases the AdV virus growth in a dose-dependent manner in eGFP-transinfected HEK 293 cells[2].
BRACO-19 (0-150 μM; 24 hours) shows a decrease in band intensity in an increasing concentration-dependent manner[2].

Cell Viability Assay[1]

Cell Line: HEK 293 cells
Concentration: 20 μM; 40 μM
Incubation Time: 24 hours
Result: Displayed low cytotoxicity and decreased the eGFP fluorescence.
In Vivo

BRACO-19 (oral administration or intraperitoneal injection; 2 or 5 mg/kg; 3 weeks) oral dosing regimen are always inactive and the animals have to be sacrificed due to high tumor burden before overall termination of the study, Chronic, i.p. BRACO-19 administration, qdx5 is efficient in inhibiting tumor growth in earlystage xenografts but not advanced-stage xenografts[1].
BRACO-19 (intraperitoneal injection; 2 mg/kg; 3 weeks; starting 6 days after transplantation of UXF1138LX fragments) inhibits tumor growth significantly and under these conditions, marked single-agent antitumor activity is observed, with some animals in the group showing complete regressions (5 of 12 tumors)[1].

Animal Model: Established UXF1138LX Xenografts in nude mice[1]
Dosage: 2 mg/kg
Administration: Intraperitoneal injection; 3 weeks; starting 6 days after transplantation of UXF1138LX fragments
Result: Showed partial tumor regressions with an optimal T/C on day 28 of 4.1%, equal to 95.9% inhibition of tumor growth compared with control.
Molecular Weight

593.76

Formula

C₃₅H₄₃N₇O₂

CAS No.

351351-75-2

SMILES

CN(C1=CC=C(NC2=C(C=CC(NC(CCN3CCCC3)=O)=C4)C4=NC5=CC(NC(CCN6CCCC6)=O)=CC=C52)C=C1)C

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Braco-19Braco19Braco 19CMVDNA/RNA SynthesisCytomegalovirustelomertelomeraseUXF1138LuteruscarcinomaHAdVG-quadruplexHuman AdenovirusAdenoviruseseGFPHEK 293Inhibitorinhibitorinhibit

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