Braco-19 trihydrochloride
Based on 5 publication(s) in Google Scholar
Braco-19 trihydrochloride is a potent telomerase/telomere inhibitor, preventing the capping and catalytic action of telomerase. Braco-19 acts as G-quadruplex (GQ) binding ligand, stabilizing G-quadruplexes formation at the 3V telomeric DNA overhang and produce rapid senescence or selective cell death. Braco-19 is also a HAdV virus replication inhibitor.
For research use only. We do not sell to patients.
- Purity: 99.57%
- CAS No.: 1177798-88-7
- Formula: C35H46Cl3N7O2
- Molecular Weight:703.14
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Braco-19 trihydrochloride
MoreAll DNA/RNA Synthesis Isoforms
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Biological Activity
IC50: telomerase[1]
Braco-19 trihydrochloride, as a well-known GQ binding ligand, interacts specifically with the HAdV GQs and increases their stability, and blocks the HAdV multiplication[2].BRACO-19 trihydrochloride (1 μM; 24 hours) shows dramatically reduced nuclear hTERT expression. However, residual cytoplasmic hTERT staining is observed accompanied by the occurrence of atypical mitoses[1].BRACO-19 trihydrochloride (0-40 μM; 24 hours) decreases the AdV virus growth in a dose-dependent manner in eGFP-transinfected HEK 293 cells[2].BRACO-19 trihydrochloride (0-150 μM; 24 hours) shows a decrease in band intensity in an increasing concentration-dependent manner[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEK 293 cells
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Concentration:20 μM; 40 μM
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Incubation Time:24 hours
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Result:Displayed low cytotoxicity and decreased the eGFP fluorescence.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Established UXF1138LX Xenografts in nude mice[1]
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Dosage:2 mg/kg
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Administration:Intraperitoneal injection; 3 weeks; starting 6 days after transplantation of UXF1138LX fragments
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Result:Showed partial tumor regressions with an optimal T/C on day 28 of 4.1%, equal to 95.9% inhibition of tumor growth compared with control.
Chemical Information
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CAS No. 1177798-88-7
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Appearance Solid
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Molecular Weight 703.14
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Formula C35H46Cl3N7O2
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Color Yellow to brown
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SMILES
CN(C1=CC=C(NC2=C(C=CC(NC(CCN3CCCC3)=O)=C4)C4=NC5=CC(NC(CCN6CCCC6)=O)=CC=C52)C=C1)C.Cl.Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (5)
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Journal Impact Factor
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Most Recent
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Nat Cell Biol
Targeting specific DNA G-quadruplexes with CRISPR-guided G-quadruplex-binding proteins and ligands. [Abstract]2024 Jul;26(7):1212-1224. PMID: 38961283 -
Biochim Biophys Acta Mol Basis Dis
The sonic hedgehog pathway suppresses oxidative stress and senescence in nucleus pulposus cells to alleviate intervertebral disc degeneration via GPX4. [Abstract]2023 Nov 16;1870(2):166961. PMID: 37979732 -
iScience
Genomic G-quadruplex folding triggers a cytokine-mediated inflammatory feedback loop to aggravate inflammatory diseases. [Abstract]2022 Oct 9;25(11):105312. PMID: 36304116 -
Microbiol Spectr
Characterization of G-Quadruplexes in Enterovirus A71 Genome and Their Interaction with G-Quadruplex Ligands. [Abstract]2022 Apr 21;e0046022. PMID: 35446122 -
SLAS Discov
A high-throughput approach to evaluating NCp7 RNA binding activity for HIV-1 drug discovery. [Abstract]2025 Aug 11:35:100260. PMID: 40803428
Solvent & Solubility
DMSO : 50 mg/mL (71.11 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 22 mg/mL (31.29 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (479 KB)
- English - EN (479 KB)
- Français - FR (479 KB)
- Deutsch - DE (479 KB)
- Norwegian - NO (479 KB)
- Español - ES (479 KB)
- Swedish - SV (479 KB)
- Italian - IT (479 KB)
- Korean - KR (479 KB)
- Portuguese - PT (479 KB)
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Handling Instructions (2659 KB)
References
[1]. Angelika M Burger, et al. The G-quadruplex-interactive Molecule BRACO-19 Inhibits Tumor Growth, Consistent With Telomere Targeting and Interference With Telomerase Function. Cancer Res. 2005 Feb 15;65(4):1489-96. [Content Brief]
[2]. Prativa Majee, et al. Genome-wide Analysis Reveals a Regulatory Role for G-quadruplexes During Adenovirus Multiplication. Virus Res. . 2020 Jul 2;283:197960. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 1.4222 mL | 7.1110 mL | 14.2219 mL | 35.5548 mL |
| 5 mM | 0.2844 mL | 1.4222 mL | 2.8444 mL | 7.1110 mL | |
| 10 mM | 0.1422 mL | 0.7111 mL | 1.4222 mL | 3.5555 mL | |
| 15 mM | 0.0948 mL | 0.4741 mL | 0.9481 mL | 2.3703 mL | |
| 20 mM | 0.0711 mL | 0.3555 mL | 0.7111 mL | 1.7777 mL | |
| 25 mM | 0.0569 mL | 0.2844 mL | 0.5689 mL | 1.4222 mL | |
| 30 mM | 0.0474 mL | 0.2370 mL | 0.4741 mL | 1.1852 mL | |
| DMSO | 40 mM | 0.0356 mL | 0.1778 mL | 0.3555 mL | 0.8889 mL |
| 50 mM | 0.0284 mL | 0.1422 mL | 0.2844 mL | 0.7111 mL | |
| 60 mM | 0.0237 mL | 0.1185 mL | 0.2370 mL | 0.5926 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Braco-19 trihydrochloride Related Classifications
HY-15523A Related Classifications
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