Synthesis and biological evaluation of novel 4,5-bis(dialkylaminoalkyl)-substituted acridines as potent telomeric G-quadruplex ligands

  • Eur J Med Chem. 2009 Oct;44(10):3880-8. doi: 10.1016/j.ejmech.2009.04.021.
Marie Laronze-Cochard  1 ,  Young-Min Kim ,  Bertrand Brassart ,  Jean-François Riou ,  Jean-Yves Laronze ,  Janos Sapi
Affiliations
  • 1. Université de Reims-Champagne-Ardenne, Institut de Chimie Moléculaire de Reims, CNRS UMR 6229, IFR 53 Biomolécules, Faculté de Pharmacie, 51 rue de Cognacq-Jay, F-51096 Reims, France.
PMID: 19467742 DOI: 10.1016/j.ejmech.2009.04.021
Abstract

Several 4,5-bis(dialkylaminoalkyl)-substituted acridines have been prepared starting from acridine and their telomeric G-quadruplex stabilizing properties were evaluated using FRET melting and TRAP (Telomerase Repeat Amplification Protocol Assay) experiments.