Synthesis and evaluation of bis(imino)anthracene derivatives as G-quadruplex ligands

  • RSC Med Chem. 2021 Mar 26;12(5):751-757. doi: 10.1039/d0md00428f.
Tomris Coban  1 ,  Cameron Robertson  1 ,  Sianne Schwikkard  1 ,  Richard Singer  1 ,  Adam LeGresley  1
Affiliations
  • 1. LSP&C, SEC Faculty, Kingston University Kingston-upon-Thames KT1 2EE UK [email protected].
PMID: 34124673 DOI: 10.1039/d0md00428f
Abstract

The synthesis of a small number of bis(imino)anthracene derivatives is reported. They were evaluated via NMR for binding efficacy to the G-quadruplex-forming oligonucleotide sequence (TTGGGTT) and show activity against the HeLa Cancer cell line. These novel ligands are compared to previously synthesised G-quadruplex ligands that target telomeres and oncogenes.