2. Cell Cycle/DNA Damage
  3. G-quadruplex
  4. SOP1812

SOP1812 (QN-302) is a naphthalene diimide (ND) derivative with anti-tumor activity. SOP1812 binds to quadruplex arrangements (G4s), and down-regulates several cancer gene pathways. SOP1812 shows great affinity to hTERT G4 and HuTel21 G4 with KD values of 4.9 and 28.4 nM, respectively. SOP1812 can be used for the research of cancer.

For research use only. We do not sell to patients.

SOP1812 Chemical Structure

SOP1812 Chemical Structure

CAS No. : 2546091-70-5

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 741 In-stock
Solution
10 mM * 1 mL in DMSO USD 741 In-stock
Solid
5 mg USD 500 In-stock
10 mg USD 780 In-stock
25 mg USD 1280 In-stock
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100 mg USD 3280 In-stock
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Based on 1 publication(s) in Google Scholar

SOP1812 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

SOP1812 (QN-302) is a naphthalene diimide (ND) derivative with anti-tumor activity. SOP1812 binds to quadruplex arrangements (G4s), and down-regulates several cancer gene pathways. SOP1812 shows great affinity to hTERT G4 and HuTel21 G4 with KD values of 4.9 and 28.4 nM, respectively. SOP1812 can be used for the research of cancer[1].

In Vitro

SOP1812 (0-50 nM; 96 h) inhibits the proliferation of many cancer cells[1].
SOP1812 (0-800 nM; 6-24 h) shows great affinity to hTERT G4 and HuTel21 G4[1].
SOP1812 (40 nM; 6-24 h) affects Wnt/β-catenin, axon guidance, Hippo, MAPK and Rap1 pathways[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SOP1812 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: MIA PaCa-2, PANC-1, Capan-1 and BxPC-3 cell lines
Concentration: 0-50 nM
Incubation Time: 96 hours
Result: Showed anti-proliferation ability to MIA PaCa-2, PANC-1, Capan-1 and BxPC-3 cells with GI50 values of 1.3, 1.4, 5.9 and 2.6 nM, respectively.

Cell Viability Assay[1]

Cell Line: PANC-1 cells
Concentration: 0, 100, 400 and 800 nM
Incubation Time: 6 and 24 hours
Result: Binded to hTERT G4 and HuTel21 G4 with KD values of 4.9 and 28.4 nM, respectively.

Cell Viability Assay[1]

Cell Line: MIA PaCa-2 Cells
Concentration: 40 nM
Incubation Time: 6 and 24 hours
Result: Affected WNT5B, DVL1, AXIN and APC2 expression which includes in Wnt/β-catenin pathway and also showed effects on axon guidance, Hippo, MAPK, and Rap1 pathways.
In Vivo

SOP1812 (1 mg/kg; i.v. once or twice per week for 28 days) shows anti-tumor activity in MIA PaCa-2 xenografts mice and KPC mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female athymic nude mice with MIA PaCa-2 xenografts[1]
Dosage: 1 mg/kg
Administration: Intravenous injection; 1 mg/kg once or twice per week; for 28 days
Result: Showed complete tumor regression and no significant tumor regrowth after day 28 on several animals.
Animal Model: KPC mice with PDAC symptoms[1]
Dosage: 1 mg/kg
Administration: Intravenous injection; 1 mg/kg once per week; for 3 weeks
Result: Significantly extended survival of KPC mice and showed a better effect than gemcitabine.
Molecular Weight

791.98

Formula

C45H57N7O6
CAS No.
Appearance

Solid

Color

Brown to reddish brown

SMILES

O=C1C2=CC(NCCN3CCCC3)=C4C(N(CCCN5CCOCC5)C(C6=CC(C7=CC=C(CN8CCCC8)C=C7)=C(C2=C64)C(N1CCCN9CCOCC9)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (252.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2627 mL 6.3133 mL 12.6266 mL
5 mM 0.2525 mL 1.2627 mL 2.5253 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2627 mL 6.3133 mL 12.6266 mL 31.5665 mL
5 mM 0.2525 mL 1.2627 mL 2.5253 mL 6.3133 mL
10 mM 0.1263 mL 0.6313 mL 1.2627 mL 3.1566 mL
15 mM 0.0842 mL 0.4209 mL 0.8418 mL 2.1044 mL
20 mM 0.0631 mL 0.3157 mL 0.6313 mL 1.5783 mL
25 mM 0.0505 mL 0.2525 mL 0.5051 mL 1.2627 mL
30 mM 0.0421 mL 0.2104 mL 0.4209 mL 1.0522 mL
40 mM 0.0316 mL 0.1578 mL 0.3157 mL 0.7892 mL
50 mM 0.0253 mL 0.1263 mL 0.2525 mL 0.6313 mL
60 mM 0.0210 mL 0.1052 mL 0.2104 mL 0.5261 mL
80 mM 0.0158 mL 0.0789 mL 0.1578 mL 0.3946 mL
100 mM 0.0126 mL 0.0631 mL 0.1263 mL 0.3157 mL
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SOP1812 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SOP18122546091-70-5QN-302SOP 1812SOP-1812QN302QN 302G-quadruplexNDquadruplexMIA PaCa-2G4Wnt/β-cateninPANC-1BxPC-3PDACInhibitorinhibitorinhibit

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