2. Cell Cycle/DNA Damage Autophagy Apoptosis
  3. G-quadruplex Autophagy c-Myc
  4. SYUIQ-5

SYUIQ-5 is a G-quadruplex ligand. SYUIQ-5 stabilizes G-quadruplex and induce senescence. SYUIQ-5 inhibits c-myc gene promoter activity. SYUIQ-5 induces cancer cells autophagy by triggering telomere damage through TRF2 delocalization from telomeres.

For research use only. We do not sell to patients.

SYUIQ-5

SYUIQ-5 Chemical Structure

CAS No. : 188630-47-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
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5 mg In-stock
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SYUIQ-5 Related Antibodies

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Description

SYUIQ-5 is a G-quadruplex ligand. SYUIQ-5 stabilizes G-quadruplex and induce senescence. SYUIQ-5 inhibits c-myc gene promoter activity. SYUIQ-5 induces cancer cells autophagy by triggering telomere damage through TRF2 delocalization from telomeres[1].

Cellular Effect
Cell Line Type Value Description References
Bel-7402 IC50
0.24 μM
Compound: 1, SYUIQ-05
Cytotoxicity in human Bel7402 cells by MTT assay
Cytotoxicity in human Bel7402 cells by MTT assay
[PMID: 21774525]
CNE-2 IC50
0.24 μM
Compound: 1, SYUIQ-05
Cytotoxicity in human CNE2 cells by MTT assay
Cytotoxicity in human CNE2 cells by MTT assay
[PMID: 21774525]
HL-60 IC50
0.24 μM
Compound: 1, SYUIQ-05
Cytotoxicity in human HL60 cells by MTT assay
Cytotoxicity in human HL60 cells by MTT assay
[PMID: 21774525]
HeLa IC50
0.24 μM
Compound: 1, SYUIQ-05
Cytotoxicity in human HeLa cells by MTT assay
Cytotoxicity in human HeLa cells by MTT assay
[PMID: 21774525]
K562 IC50
0.24 μM
Compound: 1, SYUIQ-05
Cytotoxicity in human K562 cells by MTT assay
Cytotoxicity in human K562 cells by MTT assay
[PMID: 21774525]
K562 IC50
2.6 μM
Compound: 3
Cytotoxicity against human K562 cells assessed as cell viability by MTT assay
Cytotoxicity against human K562 cells assessed as cell viability by MTT assay
[PMID: 35716866]
MCF7 IC50
0.63 μM
Compound: 1
Inhibition of telomerase in human MCF7 cells by cell-free telomerase repeat amplification protocol assay
Inhibition of telomerase in human MCF7 cells by cell-free telomerase repeat amplification protocol assay
[PMID: 18821749]
MGC-803 IC50
0.24 μM
Compound: 1, SYUIQ-05
Cytotoxicity in human MGC803 cells by MTT assay
Cytotoxicity in human MGC803 cells by MTT assay
[PMID: 21774525]
SUNE1 IC50
0.24 μM
Compound: 1, SYUIQ-05
Cytotoxicity in human SUNE1 cells by MTT assay
Cytotoxicity in human SUNE1 cells by MTT assay
[PMID: 21774525]
SW-620 IC50
1.7 μM
Compound: 3
Cytotoxicity against human SW-620 cells assessed as cell viability by MTT assay
Cytotoxicity against human SW-620 cells assessed as cell viability by MTT assay
[PMID: 35716866]
Molecular Weight

318.42

Formula

C20H22N4
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

CN(C)CCCNC(C1=C(C=CC=C1)N=C23)=C3NC4=C2C=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (314.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1405 mL 15.7025 mL 31.4051 mL
5 mM 0.6281 mL 3.1405 mL 6.2810 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.03%

SDS (398 KB)

COA (254 KB) HNMR (141 KB) RP-HPLC (175 KB) LCMS (105 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1405 mL 15.7025 mL 31.4051 mL 78.5127 mL
5 mM 0.6281 mL 3.1405 mL 6.2810 mL 15.7025 mL
10 mM 0.3141 mL 1.5703 mL 3.1405 mL 7.8513 mL
15 mM 0.2094 mL 1.0468 mL 2.0937 mL 5.2342 mL
20 mM 0.1570 mL 0.7851 mL 1.5703 mL 3.9256 mL
25 mM 0.1256 mL 0.6281 mL 1.2562 mL 3.1405 mL
30 mM 0.1047 mL 0.5234 mL 1.0468 mL 2.6171 mL
40 mM 0.0785 mL 0.3926 mL 0.7851 mL 1.9628 mL
50 mM 0.0628 mL 0.3141 mL 0.6281 mL 1.5703 mL
60 mM 0.0523 mL 0.2617 mL 0.5234 mL 1.3085 mL
80 mM 0.0393 mL 0.1963 mL 0.3926 mL 0.9814 mL
100 mM 0.0314 mL 0.1570 mL 0.3141 mL 0.7851 mL
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SYUIQ-5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SYUIQ-5188630-47-9SYUIQ5SYUIQ 5G-quadruplexAutophagyc-MycMycautophagyTRF2telomeresInhibitorinhibitorinhibit

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