SYUIQ-5
Based on 1 Customer Validation
SYUIQ-5 is a G-quadruplex ligand. SYUIQ-5 stabilizes G-quadruplex and induce senescence. SYUIQ-5 inhibits c-myc gene promoter activity. SYUIQ-5 induces cancer cells autophagy by triggering telomere damage through TRF2 delocalization from telomeres.
For research use only. We do not sell to patients.
- Purity: 99.03%
- CAS No.: 188630-47-9
- Formula: C20H22N4
- Molecular Weight:318.42
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Bel-7402 | IC50 |
0.24 μM
Compound: 1, SYUIQ-05
|
Cytotoxicity in human Bel7402 cells by MTT assay
Cytotoxicity in human Bel7402 cells by MTT assay
|
[PMID: 21774525] |
| CNE-2 | IC50 |
0.24 μM
Compound: 1, SYUIQ-05
|
Cytotoxicity in human CNE2 cells by MTT assay
Cytotoxicity in human CNE2 cells by MTT assay
|
[PMID: 21774525] |
| HeLa | IC50 |
0.24 μM
Compound: 1, SYUIQ-05
|
Cytotoxicity in human HeLa cells by MTT assay
Cytotoxicity in human HeLa cells by MTT assay
|
[PMID: 21774525] |
| HL-60 | IC50 |
0.24 μM
Compound: 1, SYUIQ-05
|
Cytotoxicity in human HL60 cells by MTT assay
Cytotoxicity in human HL60 cells by MTT assay
|
[PMID: 21774525] |
| K562 | IC50 |
0.24 μM
Compound: 1, SYUIQ-05
|
Cytotoxicity in human K562 cells by MTT assay
Cytotoxicity in human K562 cells by MTT assay
|
[PMID: 21774525] |
| K562 | IC50 |
2.6 μM
Compound: 3
|
Cytotoxicity against human K562 cells assessed as cell viability by MTT assay
Cytotoxicity against human K562 cells assessed as cell viability by MTT assay
|
[PMID: 35716866] |
| MCF7 | IC50 |
0.63 μM
Compound: 1
|
Inhibition of telomerase in human MCF7 cells by cell-free telomerase repeat amplification protocol assay
Inhibition of telomerase in human MCF7 cells by cell-free telomerase repeat amplification protocol assay
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[PMID: 18821749] |
| MGC-803 | IC50 |
0.24 μM
Compound: 1, SYUIQ-05
|
Cytotoxicity in human MGC803 cells by MTT assay
Cytotoxicity in human MGC803 cells by MTT assay
|
[PMID: 21774525] |
| SUNE1 | IC50 |
0.24 μM
Compound: 1, SYUIQ-05
|
Cytotoxicity in human SUNE1 cells by MTT assay
Cytotoxicity in human SUNE1 cells by MTT assay
|
[PMID: 21774525] |
| SW-620 | IC50 |
1.7 μM
Compound: 3
|
Cytotoxicity against human SW-620 cells assessed as cell viability by MTT assay
Cytotoxicity against human SW-620 cells assessed as cell viability by MTT assay
|
[PMID: 35716866] |
Chemical Information
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CAS No. 188630-47-9
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Appearance Solid
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Molecular Weight 318.42
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Formula C20H22N4
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Color White to yellow
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SMILES
CN(C)CCCNC(C1=C(C=CC=C1)N=C23)=C3NC4=C2C=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (314.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (398 KB)
- English - EN (398 KB)
- Français - FR (398 KB)
- Deutsch - DE (398 KB)
- Norwegian - NO (398 KB)
- Español - ES (398 KB)
- Swedish - SV (398 KB)
- Italian - IT (398 KB)
- Korean - KR (398 KB)
- Portuguese - PT (398 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1405 mL | 15.7025 mL | 31.4051 mL | 78.5127 mL |
| 5 mM | 0.6281 mL | 3.1405 mL | 6.2810 mL | 15.7025 mL | |
| 10 mM | 0.3141 mL | 1.5703 mL | 3.1405 mL | 7.8513 mL | |
| 15 mM | 0.2094 mL | 1.0468 mL | 2.0937 mL | 5.2342 mL | |
| 20 mM | 0.1570 mL | 0.7851 mL | 1.5703 mL | 3.9256 mL | |
| 25 mM | 0.1256 mL | 0.6281 mL | 1.2562 mL | 3.1405 mL | |
| 30 mM | 0.1047 mL | 0.5234 mL | 1.0468 mL | 2.6171 mL | |
| 40 mM | 0.0785 mL | 0.3926 mL | 0.7851 mL | 1.9628 mL | |
| 50 mM | 0.0628 mL | 0.3141 mL | 0.6281 mL | 1.5703 mL | |
| 60 mM | 0.0523 mL | 0.2617 mL | 0.5234 mL | 1.3085 mL | |
| 80 mM | 0.0393 mL | 0.1963 mL | 0.3926 mL | 0.9814 mL | |
| 100 mM | 0.0314 mL | 0.1570 mL | 0.3141 mL | 0.7851 mL |
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