2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. G-quadruplex
  5. G-quadruplex Inhibitor

G-quadruplex Inhibitor

G-quadruplex Inhibitors (4):

Cat. No. Product Name Effect Purity
  • HY-108477
    TMPyP4 tosylate
    		Inhibitor 98.0%
    TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand. TMPyP4 tosylate inhibits the interaction between G-quadruplexes and IGF-1. TMPyP4 tosylate is a telomerase inhibitor and inhibits cancer cells proliferation. TMPyP4 tosylate is also a stabilizer of nucleic acid secondary structure and an acetylcholinesterase inhibitor. Besides, TMPyP4 tosylate has antiviral activity against SARS-CoV-2.
  • HY-15594A
    Phen-DC3 Trifluoromethanesulfonate
    		Inhibitor 98.64%
    Phen-DC3 Trifluoromethanesulfonate is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC50s of 65±6 and 50±10 nM, respectively.
  • HY-182706
    NSC 373981
    		Inhibitor
    NSC 373981 is a CARD11 G4 stabilizer. NSC 373981 stabilizes the CARD11 G4 structure and inhibits CARD11 transcription in cells. NSC 373981 also inhibits BCL2 and MYC. NSC 373981 suppresses the transcription of KRAS and TERT. NSC 373981 exhibits anticancer activity against diffuse large B-cell lymphoma.
  • HY-170643
    G4/hTERT-IN-4
    		Inhibitor 98.55%
    G4/hTERT-IN-4 (compound b4) is a potent inhibitor of G4/hTERT. G4/hTERT-IN-4 plays an important role in cancer research.