95455-02-0
95455-02-0
Chemical Structure
NSC 373981
- CAS No.: 95455-02-0
- Formula:C14H11NO4
- Molecular Weight:257.24
InChIKey: DMTZMRKTFPMXSU-UHFFFAOYSA-N
SMILES: OCCC1=C([N+]([O-])=O)OC2=CC=C3C=CC=CC3=C21
Biological Activity: NSC 373981 is a CARD11 G4 stabilizer. NSC 373981 stabilizes the CARD11 G4 structure and inhibits CARD11 transcription in cells. NSC 373981 also inhibits BCL2 and MYC. NSC 373981 suppresses the transcription of KRAS and TERT. NSC 373981 exhibits anticancer activity against diffuse large B-cell lymphoma[1][2].
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NSC 373981 | NSC 373981 is a CARD11 G4 stabilizer. NSC 373981 stabilizes the CARD11 G4 structure and inhibits CARD11 transcription in cells. NSC 373981 also inhibits BCL2 and MYC. NSC 373981 suppresses the transcription of KRAS and TERT. NSC 373981 exhibits anticancer activity against diffuse large B-cell lymphoma. | |||||||||||||||||||||
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References
- [1]. Reid J M, et al. Pharmacokinetics and in vivo metabolism of the naphthofuran NSC373981 in male nu/nu mice[J]. Cancer Research, 2013, 73(8_Supplement): 2462-2462.
- [2]. Swafford K, et al. Targeting a Novel G-Quadruplex in the CARD11 Oncogene Promoter with Naptho(2,1-b)furan-1-ethanol,2-nitro- Requires the Nitro Group. Genes (Basel). 2022 Jun 25;13(7):1144. [Content Brief]
Keywords
