1. Cell Cycle/DNA Damage
  2. G-quadruplex
  3. Pyridostatin

Pyridostatin (Synonyms: RR82)

Cat. No.: HY-15176
Handling Instructions

Pyridostatin is a G-quadruplexe stabilizer, with a Kd of 490 nM.

For research use only. We do not sell to patients.

Pyridostatin Chemical Structure

Pyridostatin Chemical Structure

CAS No. : 1085412-37-8

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Other In-stock Forms of Pyridostatin:

Other Forms of Pyridostatin:

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Pyridostatin is a G-quadruplexe stabilizer, with a Kd of 490 nM.

IC50 & Target

Kd: 490 nM (G-quadruplexe)[1]

In Vitro

Pyridostatin is a G-quadruplexe stabilizer, with a Kd of 490 nM[1]. Pyridostatin (PDS) shows neurotoxic activity against primary cortical neurons at 0.01-5 μM, causes DNA double-strand breaks (DSBs) at 1 μM, downregulates BRCA1 in neurons at 1, 2 or 5 μM[2]. Pyridostatin interacts with G-quadruplex motifs in SRC and alters mRNA levels of damaged genes[3].

Molecular Weight









Room temperature in continental US; may vary elsewhere.


Please store the product under the recommended conditions in the Certificate of Analysis.

Cell Assay

Cells are plated at equal confluence and either untreated or treated with 2 μM Pyridostatin continually for 72 h. Cells from individual plates are trypsinized and counted in a Coultercounter. Graphs represent total cell numbers at each time interval and error bars represent S.E.M. Data represent three independent experiments[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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PyridostatinRR82RR 82RR-82G-quadruplexInhibitorinhibitorinhibit

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