1140964-99-3
1140964-99-3
Chemical Structure
Stenoparib
Synonym(s): E7449; 2X-121
- CAS No.: 1140964-99-3
- Formula:C18H15N5O
- Molecular Weight:317.34
IUPAC Name: 8-(isoindolin-2-ylmethyl)-1,2-dihydro-3H-pyridazino[3,4,5-de]quinazolin-3-one
InChIKey: JLFSBHQQXIAQEC-UHFFFAOYSA-N
SMILES: O=C1NNC2=C3C1=CC=CC3=NC(CN4CC5=C(C=CC=C5)C4)=N2
Biological Activity: Stenoparib (E7449) is a potent PARP1 and PARP2 inhibitor and also inhibits TNKS1 and TNKS2, with IC50s of 2.0, 1.0, ～50 and ～50 nM for PARP1, PARP2, TNKS1 and TNKS2, respectively, using 32P-NAD+ as substrate.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Stenoparib | 98.0% | Stenoparib (E7449) is a potent PARP1 and PARP2 inhibitor and also inhibits TNKS1 and TNKS2, with IC50s of 2.0, 1.0, ～50 and ～50 nM for PARP1, PARP2, TNKS1 and TNKS2, respectively, using 32P-NAD+ as substrate. | ||||||||||||||||||||
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Keywords
