hCYP1B1-IN-2
hCYP1B1-IN-2 (compound 3n) is a potent human cytochrome P450 1B1 enzyme hCYP1B1 inhibitor. hCYP1B1-IN-2 shows the extremely potent anti-hCYP1B1 activity (IC50=0.040 nM) and blocks AhR transcription activity. hCYP1B1-IN-2 potently inhibits hCYP1B1 via a mix inhibition manner, showing a Ki value of 21.71 pM.
For research use only. We do not sell to patients.
- CAS No.: 3043683-33-3
- Formula: C17H10BrN3O2
- Molecular Weight:368.18
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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CYP1B1 0.040 nM (IC50) |
CYP1A1 0.38 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NCI-H460 | IC50 |
100.8 nM
Compound: 3n
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Synergistic anti-cancer activity of human PTX-resistant NCI-H460 cells assessed as PTX IC50 at 5 uM incubated for 48 hrs in presence of PTX by CCK8 assay
Synergistic anti-cancer activity of human PTX-resistant NCI-H460 cells assessed as PTX IC50 at 5 uM incubated for 48 hrs in presence of PTX by CCK8 assay
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[PMID: 38692523] |
hCYP1B1-IN-2 (compound 3n) (5 μM) can significantly reverse the Paclitaxel (PTX, HY-B0015) resistance in H460/PTX cells, evidenced by the dramatically reduced IC50 values, from 632.6 nM (PTX alone) to 100.8 nM (PTX plus 3n)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3043683-33-3
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Molecular Weight 368.18
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Formula C17H10BrN3O2
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SMILES
O=C(N(CC1=CN=CN=C1)C2=O)C3=CC=C(Br)C4=CC=CC2=C43
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
hCYP1B1-IN-2 Related Classifications
HY-161649 Related Classifications
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