1. Cell Cycle/DNA Damage
    Epigenetics
  2. PARP

UPF 1069 

Cat. No.: HY-14478
Handling Instructions

UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM; ~27-fold selective against PARP1.

For research use only. We do not sell to patients.
UPF 1069 Chemical Structure

UPF 1069 Chemical Structure

CAS No. : 1048371-03-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $99 In-stock
10 mg $90 In-stock
50 mg $290 In-stock
100 mg   Get quote  
200 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • References

Description

UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM; ~27-fold selective against PARP1. IC50 Value: 0.3 μM Target: PARP2 in vitro: In organotypic hippocampal slices, PARP-2 inhibition with UPF-1069 (0.01-1 micromolxL(-1)) caused a concentration-dependent exacerbation (up to 155%) of OGD-induced CA1 pyramidal cell death. Higher concentrations, acting on both PARP-1 and PARP-2, had no effect on OGD injury [1]. in vivo: In organotypic hippocampal slices, PARP-2 inhibition with UPF-1069 (0.01-1 mM) causes a concentration-dependent exacerbation (up to 155%) of oxygen-glucose deprivation (OGD)-induced CA1 pyramidal cell death. Higher concentrations, acting on both PARP-1 and PARP-2, have no effect on OGD injury. In mouse mixed cortical cells exposed to OGD, UPF-1069 (1-10 mM) significantly reduces post-ischaemic damage. Clinical trial: N/A

References
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 3.5805 mL 17.9025 mL 35.8051 mL
5 mM 0.7161 mL 3.5805 mL 7.1610 mL
10 mM 0.3581 mL 1.7903 mL 3.5805 mL
References
Molecular Weight

279.29

Formula

C₁₇H₁₃NO₃

CAS No.

1048371-03-4

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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UPF 1069
Cat. No.:
HY-14478
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