1. Apoptosis
  2. RIP kinase
  3. GSK-843

GSK-843 (Synonyms: GSK'843)

Cat. No.: HY-125402 Purity: 98.43%
Handling Instructions

GSK-843 (GSK'843) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 8.6 nM, and inhibits kinase activity with an IC50 of 6.5 nM.

For research use only. We do not sell to patients.

GSK-843 Chemical Structure

GSK-843 Chemical Structure

CAS No. : 1601496-05-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 187 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 187 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 225 In-stock
Estimated Time of Arrival: December 31
10 mg USD 380 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

GSK-843 (GSK'843) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 8.6 nM, and inhibits kinase activity with an IC50 of 6.5 nM[1].

IC50 & Target

IC50: 6.5 nM (RIP3)[1]

Molecular Weight

377.49

Formula

C₁₉H₁₅N₅S₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (132.45 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6491 mL 13.2454 mL 26.4908 mL
5 mM 0.5298 mL 2.6491 mL 5.2982 mL
10 mM 0.2649 mL 1.3245 mL 2.6491 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 4.8 mg/mL (12.72 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.51 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.43%

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Product Name:
GSK-843
Cat. No.:
HY-125402
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