1. Apoptosis
  2. RIP kinase
  3. GSK-843

GSK-843 (Synonyms: GSK'843)

Cat. No.: HY-125402 Purity: 98.43%
Handling Instructions

GSK-843 (GSK'843) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 8.6 nM, and inhibits kinase activity with an IC50 of 6.5 nM.

For research use only. We do not sell to patients.

GSK-843 Chemical Structure

GSK-843 Chemical Structure

CAS No. : 1601496-05-2

Size Stock
10 mM * 1 mL in DMSO Check price and availability
5 mg Check price and availability
10 mg Check price and availability

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Description

GSK-843 (GSK'843) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 8.6 nM, and inhibits kinase activity with an IC50 of 6.5 nM[1].

IC50 & Target

IC50: 6.5 nM (RIP3)[1]

Molecular Weight

377.49

Formula

C₁₉H₁₅N₅S₂

CAS No.

1601496-05-2

SMILES

NC1=NC=C(C2=CC(C)=NN2C)C3=C1C(C4=CC=C(SC=N5)C5=C4)=CS3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (132.45 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6491 mL 13.2454 mL 26.4908 mL
5 mM 0.5298 mL 2.6491 mL 5.2982 mL
10 mM 0.2649 mL 1.3245 mL 2.6491 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.51 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.43%

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Keywords:

GSK-843GSK'843GSK843GSK 843RIP kinaseReceptor-interacting protein kinasesRIPKInhibitorinhibitorinhibit

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Product Name:
GSK-843
Cat. No.:
HY-125402
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