RIPK1-IN-20
RIPK1-IN-20 (compound 13c) has a favorable RIPK1 kinase inhibition activity with an IC50 value of 59.8 nM. RIPK1-IN-20 blocks TNFα-induced necroptosis in both human and murine cells (EC50=1.06–4.58 nM).
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- No. CAS: 3026543-19-8
- Fòrmula: C28H26F3N5O4
- Peso molecular:553.53
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HT-29 | EC50 |
4.58 nM
Compound: 13c
|
Anti-necroptosis activity against TSZ-induced human HT-29 cells
Anti-necroptosis activity against TSZ-induced human HT-29 cells
|
[PMID: 38171150] |
| L929 | EC50 |
1.06 nM
Compound: 13c
|
Anti-necroptosis activity against TSZ-induced mouse L929 cells
Anti-necroptosis activity against TSZ-induced mouse L929 cells
|
[PMID: 38171150] |
| U-937 | EC50 |
3.09 nM
Compound: 13c
|
Anti-necroptosis activity against TSZ-induced human U-937 cells
Anti-necroptosis activity against TSZ-induced human U-937 cells
|
[PMID: 38171150] |
Chemical Information
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No. CAS 3026543-19-8
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Peso molecular 553.53
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Fòrmula C28H26F3N5O4
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SMILES
O=C(N1CCC2=CC(C3=CN(CC4(COC4)C)C5=C3C(N)=NNC5=O)=CC=C21)CC6=CC(OC(F)(F)F)=CC=C6
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)