64-77-7
64-77-7
Chemical Structure
Tolbutamide
- CAS No.: 64-77-7
- Formula:C12H18N2O3S
- Molecular Weight:270.35
IUPAC Name: N-(butylcarbamoyl)-4-methylbenzenesulfonamide
InChIKey: JLRGJRBPOGGCBT-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(C)C=C1)(NC(NCCCC)=O)=O
Biological Activity: Tolbutamide is an orally active KATP inhibitor. Tolbutamide inhibits cell proliferation, stimulates exocytosis of glucagon and reduces fetal lethality of mice. Tolbutamide can be used in the research of diabete[1][2][3][4].
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Tolbutamide | 99.69% | Tolbutamide is an orally active KATP inhibitor. Tolbutamide inhibits cell proliferation, stimulates exocytosis of glucagon and reduces fetal lethality of mice. Tolbutamide can be used in the research of diabete. | ||||||||||||||||||||
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Tolbutamide (Standard) | 99.99% | Tolbutamide (Standard) is the analytical standard of Tolbutamide. This product is intended for research and analytical applications. Tolbutamide is an orally active KATP inhibitor. Tolbutamide inhibits cell proliferation, stimulates exocytosis of glucagon and reduces fetal lethality of mice. Tolbutamide can be used in the research of diabete. | ||||||||||||||||||||
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Tolbutamide-13C | Tolbutamide-13C is the 13C-labeled Tolbutamide. Tolbutamide is a first generation potassium channel blocker, sulfonylurea oral hypoglycemic agent. | |||||||||||||||||||||
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Tolbutamide-d9 | 99.0% | Tolbutamide-d9 is the deuterium labeled Tolbutamide. Tolbutamide is a first generation potassium channel blocker, sulfonylurea oral hypoglycemic agent. | ||||||||||||||||||||
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4-Hydroxytolbutamide | 99.69% | 4-Hydroxytolbutamide (Hydroxytolbutamide) is a metabolite of Tolbutamide. 4-Hydroxytolbutamide is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic. | ||||||||||||||||||||
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4-Hydroxytolbutamide-d9 | 99.29% | 4-Hydroxytolbutamide-d9 is the deuterium labeled 4-Hydroxytolbutamide. 4-Hydroxytolbutamide (Hydroxytolbutamide) is a metabolite of Tolbutamide. 4-Hydroxytolbutamide is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic. | ||||||||||||||||||||
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Cyclamide | Cyclamide (Cicloral), an oligopeptide, can be produced by cyanobacteria algae strains. Cyclamide can be used for the research of diabetes mellitus. | |||||||||||||||||||||
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Ethyl tosylcarbamate | 98.87% | Ethyl tosylcarbamate is an intermediate in the synthesis of Gliclazide (G409877). Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM. | ||||||||||||||||||||
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Tolbutamide sodium | Tolbutamide sodium is a potent and orally active antidiabetic agent. Tolbutamide sodium induces apoptosis in a Ca2+ dependent manner in pancreatic β-cells. Tolbutamide sodium has the potential for the research of non-insulin-dependent diabetes mellitus. | |||||||||||||||||||||
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Probenecid-d14 | 99.54% | Probenecid-d14 is the deuterium labeled Probenecid. Probenecid is a potent and selective agonist of transient receptor potential vanilloid 2 (TRPV2) channels. Probenecid also inhibits pannexin 1 channels. | ||||||||||||||||||||
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Probenecid-d7 | Probenecid-d7 is deuterium-labeled Probenecid (HY-B0545). | |||||||||||||||||||||
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Tolazamide | 99.94% | Tolazamide (U-17835) is an orally active sulfonylurea agent that inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel (IC50 = 4.2 µM in HEK293 cells transfected with the human receptor). Tolazamide has anti-diabetic properties. Tolazamide can lower blood glucose in sulfonylurea class. Tolazamide decreases insulin dose while continuing to maintain adequate metabolic control. Tolazamide is able to improve or normalize hyperglycemia and HbA. | ||||||||||||||||||||
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Chlorpropamide (Standard) | 98.66% | Chlorpropamide (Standard) is the analytical standard of Chlorpropamide. This product is intended for research and analytical applications. Chlorpropamide is an oral hypoglycemic agent studied in non-insulin-dependent diabetes mellitus (NIDDM). | ||||||||||||||||||||
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Tosyl-L-arginine | 98.03% | Tosyl-L-arginine is an arginine derivative. | ||||||||||||||||||||
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Carbutamide (Standard) | 98.44% | Carbutamide (Standard) is the analytical standard of Carbutamide. This product is intended for research and analytical applications. Carbutamide (BZ-55) is an orally active and first-generation sulfonylurea with hypoglycemic activity. | ||||||||||||||||||||
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Carbutamide-d9 | Carbutamide-d9 (BZ-55-d9) is the deuterium labeled Carbutamide. Carbutamide (BZ-55) is an orally active and first-generation sulfonylurea with hypoglycemic activity. | |||||||||||||||||||||
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Carboxytolbutamide | 99.02% | Carboxytolbutamide is a toluenesulfonamide metabolite. | ||||||||||||||||||||
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Carboxytolbutamide-d6 | Carboxytolbutamide-d6 is the deuterium labeled Carboxytolbutamide. | |||||||||||||||||||||
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Carboxytolbutamide-d9 | Carboxytolbutamide-d9 is the deuterium labeled Carboxytolbutamide. | |||||||||||||||||||||
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Methyl 4-(N-(butylcarbamoyl)sulfamoyl)benzoate-d9 | 4-Carboxy tolbutamide methyl ester-d9 is the deuterium labeled 4-Carboxy tolbutamide methyl ester. | |||||||||||||||||||||
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Acetohexamide-d11 | Acetohexamide-d11 is the deuterium labeled Acetohexamide (HY-B0881). Acetohexamide is a first-generation sulfonylurea agent used in research related to type 2 diabetes; it stimulates the pancreas to secrete insulin.Acetohexamide inhibits ATP-sensitive potassium channels in the β cells of the pancreas. | |||||||||||||||||||||
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Glipizide impurity 6 | Glipizide impurity 6 is an impurity of Glipizide. | |||||||||||||||||||||
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References
- [1]. Sánchez‐Alvarez R, et al. Tolbutamide reduces glioma cell proliferation by increasing connexin43, which promotes the up‐regulation of p21 and p27 and subsequent changes in retinoblastoma phosphorylation [J]. Glia, 2006, 54(2): 125-134. [Content Brief]
- [2]. Hœy M, et al. Tolbutamide stimulates exocytosis of glucagon by inhibition of a mitochondrial‐like ATP‐sensitive K+ (KATP) conductance in rat pancreatic A‐cells [J]. The Journal of Physiology, 2000, 527(1): 109-120. [Content Brief]
- [3]. Williams A J K, et al. Tolbutamide reduces the incidence of diabetes mellitus, but not insulitis, in the non-obese-diabetic mouse [J]. Diabetologia, 1993, 36: 487-492. [Content Brief]
- [4]. Belisle R J, et al. Tolbutamide treatment of pregnant mice: repeated administration reduces fetal lethality [J]. Teratology, 1976, 13(1): 65-70. [Content Brief]
