1. Membrane Transporter/Ion Channel
  2. Na+/K+ ATPase
  3. Acevaltrate

Acevaltrate 

Cat. No.: HY-N2070 Purity: 99.56%
Handling Instructions

Acevaltrate, isolated from Valeriana glechomifolia, inhibits the Na+/K+-ATPase activity in the rat kidney and brain hemispheres with IC50s of 22.8±1.1 μM and 42.3±1.0 μM, respectively.

For research use only. We do not sell to patients.

Acevaltrate Chemical Structure

Acevaltrate Chemical Structure

CAS No. : 25161-41-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 121 In-stock
Estimated Time of Arrival: December 31
5 mg USD 110 In-stock
Estimated Time of Arrival: December 31
10 mg USD 170 In-stock
Estimated Time of Arrival: December 31
25 mg USD 340 In-stock
Estimated Time of Arrival: December 31
50 mg USD 540 In-stock
Estimated Time of Arrival: December 31
100 mg USD 850 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Acevaltrate, isolated from Valeriana glechomifolia, inhibits the Na+/K+-ATPase activity in the rat kidney and brain hemispheres with IC50s of 22.8±1.1 μM and 42.3±1.0 μM, respectively[1].

IC50 & Target

IC50: 22.8±1.1 μM (Na+/K+-ATPase, in rat kidney), 42.3±1.0 μM (Na+/K+-ATPase, in rat brain hemispheres)[1]

In Vitro

Acevaltrate differentiallys inhibit the activity of rat P-type ATPases in vitro. 60.7±7.3% inhibition of the rat H+/K+-ATPase is achieved at 100 µM[1].

Storage

4°C, protect from light

Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (260.15 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0812 mL 10.4058 mL 20.8117 mL
5 mM 0.4162 mL 2.0812 mL 4.1623 mL
10 mM 0.2081 mL 1.0406 mL 2.0812 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.33 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

480.50

Formula

C₂₄H₃₂O₁₀

CAS No.

25161-41-5

SMILES

O=C(CC(C)(C)OC(C)=O)O[[email protected]@H]1[[email protected]]2(CO2)[[email protected]]([[email protected]@H]3OC(CC(C)C)=O)([H])C(C(COC(C)=O)=CO3)=C1

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Acevaltrate
Cat. No.:
HY-N2070
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Acevaltrate

Cat. No.: HY-N2070