Acylated iridoids with cytotoxicity from Valeriana jatamansi

  • J Nat Prod. 2009 Apr;72(4):650-5. doi: 10.1021/np800716f.
Sheng Lin  1 ,  Yun-Heng Shen ,  Hui-Liang Li ,  Xian-Wen Yang ,  Tao Chen ,  Long-Hai Lu ,  Zheng-Sheng Huang ,  Run-Hui Liu ,  Xi-Ke Xu ,  Wei-Dong Zhang ,  Hui Wang
Affiliations
  • 1. Department of Phytochemistry, College of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China.
PMID: 19245261 DOI: 10.1021/np800716f
Abstract

Thirteen new acylated Iridoids, jatamanvaltrates A-M (1-13), together with nine known valepotriates (14-22), were isolated from the whole Plants of Valeriana jatamansi (syn. Valeriana wallichii). The structures of these new compounds were assigned by detailed interpretation of spectroscopic data. Jatamanvaltrates D (4) and H (9) are the first examples of naturally occurring valepotriates containing an o-hydroxybenzoyloxy moiety at C-10. All isolated compounds were tested for their cytotoxicity against lung adenocarcinoma (A549), metastatic prostate Cancer (PC-3M), colon Cancer (HCT-8), and hepatoma (Bel7402) cell lines.