VEGFR-2-IN-29
Based on 1 Customer Validation
VEGFR-2-IN-29 (Compound 5) is a VEGFR-2 inhibitor with an IC50 of 16.5 nM.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.36%
- CAS. Nr.: 62802-77-1
- Formel: C16H11N3O3
- Molecular Weight:293.28
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Alle VEGFR Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
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VEGFR-2 16.5 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| HUVEC | IC50 |
15.8 nM
Compound: 5
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Inhibition of VEGF-induced proliferation in HUVEC cells assessed as BrdU incorporation by ELISA
Inhibition of VEGF-induced proliferation in HUVEC cells assessed as BrdU incorporation by ELISA
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[PMID: 20943391] |
| HUVEC | IC50 |
210 nM
Compound: 5
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Inhibition of bEGF-induced proliferation in HUVEC cells assessed as BrdU incorporation by ELISA
Inhibition of bEGF-induced proliferation in HUVEC cells assessed as BrdU incorporation by ELISA
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[PMID: 20943391] |
VEGFR-2-IN-29 (Compound 5) (72 h) inhibits HUVEC proliferation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HUVEC
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Concentration:
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Incubation Time:72 h
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Result:Showed inhibition with IC50s of 15.8 nM and 210 nM against VEGF- and bFGF-induced HUVEC proliferation.
Chemical Information
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CAS. Nr. 62802-77-1
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Appearance Solid
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Molecular Weight 293.28
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Formel C16H11N3O3
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Color Light brown to brown
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SMILES
O=C(NC1=C2N=CC=CC2=CC=C1)C3=CC=CC([N+]([O-])=O)=C3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 20 mg/mL (68.19 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4097 mL | 17.0486 mL | 34.0971 mL | 85.2428 mL |
| 5 mM | 0.6819 mL | 3.4097 mL | 6.8194 mL | 17.0486 mL | |
| 10 mM | 0.3410 mL | 1.7049 mL | 3.4097 mL | 8.5243 mL | |
| 15 mM | 0.2273 mL | 1.1366 mL | 2.2731 mL | 5.6829 mL | |
| 20 mM | 0.1705 mL | 0.8524 mL | 1.7049 mL | 4.2621 mL | |
| 25 mM | 0.1364 mL | 0.6819 mL | 1.3639 mL | 3.4097 mL | |
| 30 mM | 0.1137 mL | 0.5683 mL | 1.1366 mL | 2.8414 mL | |
| 40 mM | 0.0852 mL | 0.4262 mL | 0.8524 mL | 2.1311 mL | |
| 50 mM | 0.0682 mL | 0.3410 mL | 0.6819 mL | 1.7049 mL | |
| 60 mM | 0.0568 mL | 0.2841 mL | 0.5683 mL | 1.4207 mL |
VEGFR-2-IN-29 Related Classifications
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