2. PROTAC Immunology/Inflammation
  3. PROTACs IRAK
  4. KTX-951

KTX-951 is a PROTAC targeting IRAK4 degradation (DC50=18 nM). KTX-951 (10 mg/kg) shows the oral bioavailability (F%) of 22% in a rat model. KTX-951 has good anticancer potential.

For research use only. We do not sell to patients.

KTX-951 Chemical Structure

KTX-951 Chemical Structure

CAS No. : 2573298-36-7

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 3136 In-stock
Solution
10 mM * 1 mL in DMSO USD 3136 In-stock
Solid
1 mg USD 720 In-stock
5 mg USD 2200 In-stock
10 mg USD 3350 In-stock
25 mg USD 6800 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

KTX-951 Related Antibodies

Top Publications Citing Use of Products

View All PROTACs Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

View All IRAK Isoform Specific Products:

View All Isoforms
IRAK1 IRAK4

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

KTX-951 is a PROTAC targeting IRAK4 degradation (DC50=18 nM). KTX-951 (10 mg/kg) shows the oral bioavailability (F%) of 22% in a rat model. KTX-951 has good anticancer potential[1].

IC50 & Target

IRAK4[1].
Molecular Weight

850.95

Formula

C46H52F2N8O6
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

FC(F)(C)C1=CC=CC(C(NC(C(OC)=CC2=N3)=CC2=CN3[C@H]4CC[C@@H](CC4)CN5CCC6(CC(CCNC7=C(C8=O)C(C(N8C(C(N9)=O)CCC9=O)=O)=CC=C7)C6)CC5)=O)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (58.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1752 mL 5.8758 mL 11.7516 mL
5 mM 0.2350 mL 1.1752 mL 2.3503 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1752 mL 5.8758 mL 11.7516 mL 29.3789 mL
5 mM 0.2350 mL 1.1752 mL 2.3503 mL 5.8758 mL
10 mM 0.1175 mL 0.5876 mL 1.1752 mL 2.9379 mL
15 mM 0.0783 mL 0.3917 mL 0.7834 mL 1.9586 mL
20 mM 0.0588 mL 0.2938 mL 0.5876 mL 1.4689 mL
25 mM 0.0470 mL 0.2350 mL 0.4701 mL 1.1752 mL
30 mM 0.0392 mL 0.1959 mL 0.3917 mL 0.9793 mL
40 mM 0.0294 mL 0.1469 mL 0.2938 mL 0.7345 mL
50 mM 0.0235 mL 0.1175 mL 0.2350 mL 0.5876 mL
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KTX-951 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KTX-9512573298-36-7KTX951KTX 951PROTACsIRAKInterleukin-1 receptor associated kinaseIL-1R associated kinasecancerInhibitorinhibitorinhibit

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