2573298-36-7
2573298-36-7
Chemical Structure
KTX-951
- CAS No.: 2573298-36-7
- Formula:C46H52F2N8O6
- Molecular Weight:850.95
InChIKey: XMUGELSEEJWFAK-UQHPAKBZSA-N
SMILES: FC(F)(C)C1=CC=CC(C(NC(C(OC)=CC2=N3)=CC2=CN3[C@H]4CC[C@@H](CC4)CN5CCC6(CC(CCNC7=C(C8=O)C(C(N8C(C(N9)=O)CCC9=O)=O)=CC=C7)C6)CC5)=O)=N1
Biological Activity: KTX-951 is an orally active IRAK4 and IMiD (Ikaros/Aiolos) substrates PROTAC degrader (Kd = 3.5 nM). KTX-951 has DC50s of 13 nM, 14 nM and 13 nM for IRAK4, Ikaros and Aiolos, respectively. KTX-951 has IC50 of 35 nM for OCl-Ly10 CTG. KTX-951 has antitumor activity[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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KTX-951 | 99.60% | KTX-951 is an orally active IRAK4 and IMiD (Ikaros/Aiolos) substrates PROTAC degrader (Kd = 3.5 nM). KTX-951 has DC50s of 13 nM, 14 nM and 13 nM for IRAK4, Ikaros and Aiolos, respectively. KTX-951 has IC50 of 35 nM for OCl-Ly10 CTG. KTX-951 has antitumor activity. | ||||||||||||||||||||
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References
Keywords
