1. Immunology/Inflammation
    Protein Tyrosine Kinase/RTK
  2. IRAK
  3. IRAK4-IN-4

IRAK4-IN-4 

Cat. No.: HY-114181 Purity: 99.72%
Handling Instructions

IRAK4-IN-4 is an interleukin-1 receptor–associated kinase 4 (IRAK4) inhibitor extracted from patent CN107163044A, Compound15, has an IC50 of 2.8 nM. IRAK4-IN-4 also inhibits cyclic GMP-AMP synthase (cGAS) with an IC50 of 2.1 nM.

For research use only. We do not sell to patients.

IRAK4-IN-4 Chemical Structure

IRAK4-IN-4 Chemical Structure

CAS No. : 1850276-58-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 262 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
25 mg USD 990 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Based on 1 publication(s) in Google Scholar

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Description

IRAK4-IN-4 is an interleukin-1 receptor–associated kinase 4 (IRAK4) inhibitor extracted from patent CN107163044A, Compound15, has an IC50 of 2.8 nM. IRAK4-IN-4 also inhibits cyclic GMP-AMP synthase (cGAS) with an IC50 of 2.1 nM[1].

IC50 & Target

IC50: 2.8 nM (IRAK4), 2.1 nM (cGAS)[1]

Molecular Weight

340.37

Formula

C₂₂H₁₆N₂O₂

CAS No.

1850276-58-2

SMILES

O=C(C1=C(C2=CC=CC=C2)N=C3C=C(C)C=CN31)C(C4=CC=CC=C4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (73.45 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9380 mL 14.6899 mL 29.3798 mL
5 mM 0.5876 mL 2.9380 mL 5.8760 mL
10 mM 0.2938 mL 1.4690 mL 2.9380 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.25 mg/mL (6.61 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.25 mg/mL (6.61 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.25 mg/mL (6.61 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

IRAK4-IN-4IRAKInterleukin-1 receptor associated kinaseIL-1R associated kinaseInhibitorinhibitorinhibit

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Product name:
IRAK4-IN-4
Cat. No.:
HY-114181
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