1287665-60-4
1287665-60-4
Chemical Structure
AS2444697
- CAS No.: 1287665-60-4
- Formula:C19H21ClN6O4
- Molecular Weight:432.86
IUPAC Name: N-(3-carbamoyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-2-(2-methylpyridin-4-yl)oxazole-4-carboxamide hydrochloride
InChIKey: FGNHLIIFEDYNFZ-UHFFFAOYSA-N
SMILES: O=C(NC1=CN(C2CCOCC2)N=C1C(N)=O)C3=COC(C4=CC=NC(C)=C4)=N3.[H]Cl
Biological Activity: AS2444697 is an orally active IRAK-4 inhibitor with an IC50 of 21 nM[1]. AS2444697 potently inhibits human and rat IRAK-4 activity. AS2444697 exhibits renoprotective effects through anti-inflammatory action[2].
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AS2444697 | 99.54% | AS2444697 is an orally active IRAK-4 inhibitor with an IC50 of 21 nM. AS2444697 potently inhibits human and rat IRAK-4 activity. AS2444697 exhibits renoprotective effects through anti-inflammatory action. | ||||||||||||||||||||
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AS2444697 (Standard) | ≥98% | AS2444697 (Standard) is the analytical standard of AS2444697 (HY-18992). This product is intended for research and analytical applications. AS2444697 is an orally active IRAK-4 inhibitor with an IC50 of 21 nM. AS2444697 potently inhibits human and rat IRAK-4 activity. AS2444697 exhibits renoprotective effects through anti-inflammatory action. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.58
HY-168611IRAK4 ligand-18 -
Similarity Score 0.54
HY-139318IRAK4 ligand-16 -
Similarity Score 0.53
HY-135317BEmavusertib hydrochloride -
Similarity Score 0.53
HY-135317Emavusertib -
Similarity Score 0.51
HY-135317DEmavusertib mesylate -
Similarity Score 0.51
HY-135317FEmavusertib phosphate -
Similarity Score 0.50
HY-135317EEmavusertib maleate -
Similarity Score 0.49
HY-155574IRAK4-IN-27 -
Similarity Score 0.48
HY-113662CLB-016 -
Explore the MedChemAI to find more analogs
References
- [1]. JohnHynesJr, et al. Chapter Nine - Advances in the Discovery of Small-Molecule IRAK4 Inhibitors. Annu Rep Med Chem. 2014 (49):117-133.
- [2]. Mitsuhiro Kondo, et al. Renoprotective effects of novel interleukin-1 receptor-associated kinase 4 inhibitor AS2444697 through anti-inflammatory action in 5/6 nephrectomized rats. Naunyn Schmiedebergs Arch Pharmacol. 2014 Oct;387(10):909-19. [Content Brief]
