IRAK4-IN-27
IRAK4-IN-27 (Compound 22) is a potent, selective inhibitor of IRAK4, with IC50 of 8.7 nM. IRAK4-IN-27 inhibits cell growth, and promotes apoptosis in MYD88 L265P diffuse large B-cell lymphoma (DLBCL) cell line. IRAK4-IN-27 can be used for DLBCL study.
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- CAS. Nr.: 2626988-86-9
- Formel: C23H22N6O3
- Molecular Weight:430.46
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Biologische Aktivität
Beschreibung
IC50 & Target
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IRAK4 8.7 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| OCI-Ly10 | IC50 |
0.248 μM
Compound: 22
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Cytotoxicity against human OCILY10 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK-8 assay
Cytotoxicity against human OCILY10 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK-8 assay
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[PMID: 37163947] |
| U2932 | IC50 |
1.251 μM
Compound: 22
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Cytotoxicity against human U2932 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK-8 assay
Cytotoxicity against human U2932 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK-8 assay
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[PMID: 37163947] |
In Vitro
IRAK4-IN-27 (Compound 22, 72 h) shows antiproliferative activity against MYD88 L265P DLBCL cell line (OCI-LY10, IC50 = 0.248 μM) and MYD88 WT cell lines (U2932, IC50 = 1.251 μM, and GM00637, IC50 = 1.520 μM) [1].
IRAK4-IN-27 (0.5 and 1 μM, 24 and 48 h) induces apoptosis in OCI-LY10 cells[1].
IRAK4-IN-27 (0.03-3 μM) inhibits phosphorylation of IRAK4 and downstream signaling in OCI-LY10 cells[1].
IRAK4-IN-27 (0.1 and 0.2 μM, 48 h) in combination with Ibrutinib (HY-10997) inhibits cell growth, but induces apoptosis in OCI-LY10 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:OCI-LY10 cells
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Concentration:0, 0.1, 0.2, 0.5, 1 μM
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Incubation Time:24 and 48 h
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Result:Triggered significant apoptosis after 24 h incubation, with apoptosis rates of 48.3% and 66.8% at the concentration of 0.5 μM and 1 μM, respectively.
Induced apoptosis of 67.2% and 92.3% after 48 h incubation at the concentration of 0.5 μM and 1 μM, respectively.
Chemical Information
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CAS. Nr. 2626988-86-9
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Molecular Weight 430.46
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Formel C23H22N6O3
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SMILES
O=C(C1=COC(C2=CC(N)=NC=C2)=N1)NC3=C(C4=CN(C)N=C4)C=C(OC(C)(C)C5)C5=C3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
IRAK4-IN-27 Related Classifications
HY-155574 Related Classifications
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