2. Metabolic Enzyme/Protease
  3. HIF/HIF Prolyl-Hydroxylase
  4. CLB-016

CLB-016 is a potent Hypoxia-inducible factor (HIF-1) inhibitor with an IC50 of 19.1 μM. CLB-016 significantly suppresses HIF-1-mediated hypoxia response.

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CLB-016

CLB-016 構造式

CAS 番号 : 1005636-29-2

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CLB-016 関連抗体

Top Publications Citing Use of Products

HIF/HIF Prolyl-Hydroxylase アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
HIF-1α HIF PHD1

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製品説明

CLB-016 is a potent Hypoxia-inducible factor (HIF-1) inhibitor with an IC50 of 19.1 μM. CLB-016 significantly suppresses HIF-1-mediated hypoxia response[1].

Cellular Effect
Cell Line Type Value Description References
HT-1080 IC50
15.1 μM
Compound: 1, CLB-016
Inhibition of cell proliferation of human HT1080 cells after 72 hrs by WST-8 dye based cell counting assay
Inhibition of cell proliferation of human HT1080 cells after 72 hrs by WST-8 dye based cell counting assay
[PMID: 25773014]
HT-1080 IC50
19.1 μM
Compound: 1, CLB-016
Inhibition of HIF1 in human HT1080 cells transfected with 5xHRE/pGL3/VEGF/E1b reporter plasmid pre-incubated for 1 hr followed by incubation under hypoxia conditions for 24 hrs by HRE-driven luciferase reporter gene assay
Inhibition of HIF1 in human HT1080 cells transfected with 5xHRE/pGL3/VEGF/E1b reporter plasmid pre-incubated for 1 hr followed by incubation under hypoxia conditions for 24 hrs by HRE-driven luciferase reporter gene assay
[PMID: 25773014]
分子量

356.38

分子式

C17H20N6O3
CAS 番号
SMILES

O=C(C1=NN(CC)C=C1NC(C2=CC=C(CN3N=C(C)C=C3C)O2)=O)N
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
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CLB-016 Related Classifications

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一般には略語で表示されます：C1V1 = C2V2

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× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CLB-0161005636-29-2CLB016CLB 016HIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHHIFhypoxia-inducible factorInhibitorinhibitorinhibit

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製品名:
CLB-016
製品番号:
HY-113662
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