2. Immunology/Inflammation Protein Tyrosine Kinase/RTK NF-κB Apoptosis
  3. IRAK FLT3 NF-κB MyD88 Apoptosis
  4. Emavusertib phosphate

Emavusertib phosphate  (Synonyms: CA-4948 phosphate)

Cat. No.: HY-135317F
Handling Instructions Technical Support

Emavusertib phosphate (CA-4948 phosphate) is the phosphate salt form of Emavusertib (HY-135317). Emavusertib phosphate is an orally active inhibitor for IRAK4 (IC50=57 nM) and FLT3. Emavusertib phosphate inhibits NF-κB and MyD88 signaling pathways, reduces the generation of pro-inflammatory cytokines like IL-6 and IL-10, thereby exhibiting anti-inflammatory and anti-proliferative activities against cancer cells, leading to cell apoptosis. Emavusertib phosphate exhibits antitumor activity in mouse model.

For research use only. We do not sell to patients.

CAS No. : 2376399-38-9

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Emavusertib phosphate Related Antibodies

Top Publications Citing Use of Products

    Emavusertib phosphate purchased from MedChemExpress. Usage Cited in: Leukemia. 2025 Sep;39(9):2163-2173.  [Abstract]

    Cell viability was determined in THP1 and HL60 cells cultured with 10 µM CA-4948 (Emavusertib) or in OCI-AML3 and K562 cultured with 1 µM CA-4948 or vehicle (n = 4) for 14 days and then treated with CC-885 (n = 4).

    Emavusertib phosphate purchased from MedChemExpress. Usage Cited in: Leukemia. 2025 Sep;39(9):2163-2173.  [Abstract]

    Immunoblots for c-MYC in the patient-derived AML samples (AML1794, AML1714) cultured with CA-4948 (Emavusertib) (10 µM) or vehicle for 14 days and then treated with CC-885 (50 nM) for 4 h.

    Emavusertib phosphate purchased from MedChemExpress. Usage Cited in: Blood. 2023 Sep 14;142(11):989-1007.  [Abstract]

    Colony formation in a panel of MDS/AML cell lines and patient-derived samples treated with the indicated concentrations of CA-4948 (Emavusertib) (1-10 μM) (2 independent experiments).

    Emavusertib phosphate purchased from MedChemExpress. Usage Cited in: Blood. 2023 Sep 14;142(11):989-1007.  [Abstract]

    IC50 curves for CA-4948 (Emavusertib) (24 h) and PF-06650833 in an assay measuring NF-kB activity upon TLR2 stimulation with PAM3CSK4 in THP1 NF-kB reporter cells.

    Emavusertib phosphate purchased from MedChemExpress. Usage Cited in: Blood. 2023 Sep 14;142(11):989-1007.  [Abstract]

    Immunoblots for phospho-IRAK1, total IRAK1, IRAK2, and IRAK4 in MDSL and AML (1714) treated for 24 hours with CA-4948 (Emavusertib) (10 μM). The results showed that treatment with CA-4948 resulted in increased IRAK1 phosphorylation.

    Emavusertib phosphate purchased from MedChemExpress. Usage Cited in: Blood. 2023 Sep 14;142(11):989-1007.  [Abstract]

    Growth curves of WT and IRAK1KO MDSL and THP1 cells treated with CA-4948 (Emavusertib) (10 μM) or vehicle. The results showed that IRAK1KO MDS/AML cells exhibited similar growth kinetics as that of WT cells.

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    Description

    Emavusertib phosphate (CA-4948 phosphate) is the phosphate salt form of Emavusertib (HY-135317). Emavusertib phosphate is an orally active inhibitor for IRAK4 (IC50=57 nM) and FLT3. Emavusertib phosphate inhibits NF-κB and MyD88 signaling pathways, reduces the generation of pro-inflammatory cytokines like IL-6 and IL-10, thereby exhibiting anti-inflammatory and anti-proliferative activities against cancer cells, leading to cell apoptosis. Emavusertib phosphate exhibits antitumor activity in mouse model[1][2][3].

    Molecular Weight

    589.49

    Formula

    C24H28N7O9P
    CAS No.
    SMILES

    O=P(O)(O)O.O=C(C1=COC(C2=CC=NC(C)=C2)=N1)NC3=C(N4CC[C@H](C4)O)N=C5C(OC(N6CCOCC6)=N5)=C3
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Emavusertib phosphate Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Emavusertib2376399-38-9CA-4948CA4948CA 4948IRAKFLT3NF-κBMyD88ApoptosisInterleukin-1 receptor associated kinaseIL-1R associated kinaseCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3Nuclear factor-κBNuclear factor-kappaBABC DLBCLMCLAMLselectiveorally activeInhibitorinhibitorinhibit

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