2767422-72-8
Chemical Structure
HS-276
- CAS No.: 2767422-72-8
- Formula:C24H29N5O2
- Molecular Weight:419.52
IUPAC Name: (R)-1-((4-acetamidophenyl)sulfonyl)-N-(2,3-dihydro-1H-inden-1-yl)-N-ethyl-4-fluoropiperidine-4-carboxamide
InChIKey: NPEMHKSMWPZEOV-UHFFFAOYSA-N
SMILES: O=C(C1=CC=CC(C(NC2=NC3=C(N2CCC)C=C(CN4CCCCC4)C=C3)=O)=C1)N
Biological Activity: HS-276 is an orally active, potent and highly selective TAK1 inhibitor, with a Ki of 2.5 nM. HS-276 shows significant inhibition of TAK1, CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1, with IC50 values of 8.25, 29, 33, 63, 125, 264, 270, 810, 1280, and 5585 nM, respectively. HS-276 reduces the expression of TNF, IL-6, and IL-1β. HS-276 can be used for rheumatoid arthritis (RA) research[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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HS-276 | 98.93% | HS-276 is an orally active, potent and highly selective TAK1 inhibitor, with a Ki of 2.5 nM. HS-276 shows significant inhibition of TAK1, CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1, with IC50 values of 8.25, 29, 33, 63, 125, 264, 270, 810, 1280, and 5585 nM, respectively. HS-276 reduces the expression of TNF, IL-6, and IL-1β. HS-276 can be used for rheumatoid arthritis (RA) research. | ||||||||||||||||||||
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Keywords
