1. Protein Tyrosine Kinase/RTK
  2. ALK
    Trk Receptor

Belizatinib (Synonyms: TSR-011)

Cat. No.: HY-17603 Purity: 99.20%
Data Sheet SDS Handling Instructions

Belizatinib is an oral, dual, potent inhibitor of ALK and TRKA, TRKB, and TRKC, with IC50 of 0.7 nM for wild-type recombinant ALK kinase.

For research use only. We do not sell to patients.
Belizatinib Chemical Structure

Belizatinib Chemical Structure

CAS No. : 1357920-84-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO $191 In-stock
2 mg $90 In-stock
5 mg $150 In-stock
10 mg $250 In-stock
50 mg $750 In-stock
100 mg $1100 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Belizatinib is an oral, dual, potent inhibitor of ALK and TRKA, TRKB, and TRKC, with IC50 of 0.7 nM for wild-type recombinant ALK kinase.

IC50 & Target

IC50: 0.7 nM (ALK)[1]

In Vitro

TSR-011 has antitumour activity in the clinical trials.

In Vivo

TSR-011 exerts sustained potent inhibition of ALK-dependent tumour growth in mouse models[1].

Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT02048488 Tesaro, Inc. Solid Tumors|Lymphomas October 2012 Phase 1|Phase 2
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References
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 1.7309 mL 8.6546 mL 17.3091 mL
5 mM 0.3462 mL 1.7309 mL 3.4618 mL
10 mM 0.1731 mL 0.8655 mL 1.7309 mL
References
Molecular Weight

577.73

Formula

C₃₃H₄₄FN₅O₃

CAS No.

1357920-84-3

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 300 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Inquiry Information

Product Name:
Belizatinib
Cat. No.:
HY-17603
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