1. Protein Tyrosine Kinase/RTK
  2. ALK
    Trk Receptor

Belizatinib (Synonyms: TSR-011)

Cat. No.: HY-17603 Purity: 99.32%
Handling Instructions

Belizatinib is an oral, dual, potent inhibitor of ALK and TRKA, TRKB, and TRKC, with IC50 of 0.7 nM for wild-type recombinant ALK kinase.

For research use only. We do not sell to patients.

Belizatinib Chemical Structure

Belizatinib Chemical Structure

CAS No. : 1357920-84-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 191 In-stock
Estimated Time of Arrival: December 31
2 mg USD 90 In-stock
Estimated Time of Arrival: December 31
5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 250 In-stock
Estimated Time of Arrival: December 31
50 mg USD 750 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Belizatinib is an oral, dual, potent inhibitor of ALK and TRKA, TRKB, and TRKC, with IC50 of 0.7 nM for wild-type recombinant ALK kinase.

IC50 & Target

IC50: 0.7 nM (ALK)[1]

In Vitro

TSR-011 has antitumour activity in the clinical trials.

In Vivo

TSR-011 exerts sustained potent inhibition of ALK-dependent tumour growth in mouse models[1].

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : ≥ 300 mg/mL (519.27 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7309 mL 8.6546 mL 17.3091 mL
5 mM 0.3462 mL 1.7309 mL 3.4618 mL
10 mM 0.1731 mL 0.8655 mL 1.7309 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

577.73

Formula

C₃₃H₄₄FN₅O₃

CAS No.

1357920-84-3

SMILES

O=C(NC1=NC2=CC=C(CN3CCC(C(C)(O)C)CC3)C=C2N1[[email protected]]4CC[[email protected]@H](C(NC(C)C)=O)CC4)C5=CC=C(F)C=C5

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.32%

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Belizatinib
Cat. No.:
HY-17603
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Belizatinib

Cat. No.: HY-17603