AM-Imidazole-PA-Boc
Based on 1 Customer Validation
AM-Imidazole-PA-Boc is an alkyl chain-based PROTAC linker can be used in the synthesis of PROTAC IRAK4 degrader-1 (HY-129966).
For research use only. We do not sell to patients.
- Purity: 98.22%
- CAS No.: 2357108-99-5
- Formula: C12H22N4O2
- Molecular Weight:254.33
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
More
Biological Activity
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Alkyl-Chain |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2357108-99-5
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Appearance Oil
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Molecular Weight 254.33
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Formula C12H22N4O2
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Color Off-white to gray
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SMILES
NCC1=CN(CCCNC(OC(C)(C)C)=O)C=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (393.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (267 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9319 mL | 19.6595 mL | 39.3190 mL | 98.2975 mL |
| 5 mM | 0.7864 mL | 3.9319 mL | 7.8638 mL | 19.6595 mL | |
| 10 mM | 0.3932 mL | 1.9659 mL | 3.9319 mL | 9.8297 mL | |
| 15 mM | 0.2621 mL | 1.3106 mL | 2.6213 mL | 6.5532 mL | |
| 20 mM | 0.1966 mL | 0.9830 mL | 1.9659 mL | 4.9149 mL | |
| 25 mM | 0.1573 mL | 0.7864 mL | 1.5728 mL | 3.9319 mL | |
| 30 mM | 0.1311 mL | 0.6553 mL | 1.3106 mL | 3.2766 mL | |
| 40 mM | 0.0983 mL | 0.4915 mL | 0.9830 mL | 2.4574 mL | |
| 50 mM | 0.0786 mL | 0.3932 mL | 0.7864 mL | 1.9659 mL | |
| 60 mM | 0.0655 mL | 0.3277 mL | 0.6553 mL | 1.6383 mL | |
| 80 mM | 0.0491 mL | 0.2457 mL | 0.4915 mL | 1.2287 mL | |
| 100 mM | 0.0393 mL | 0.1966 mL | 0.3932 mL | 0.9830 mL |
AM-Imidazole-PA-Boc Related Classifications
HY-129968 Related Classifications
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