2. PROTAC
  3. PROTAC Linkers
  4. AM-Imidazole-PA-Boc

AM-Imidazole-PA-Boc is an alkyl chain-based PROTAC linker can be used in the synthesis of PROTAC IRAK4 degrader-1 (HY-129966).

For research use only. We do not sell to patients.

AM-Imidazole-PA-Boc Chemical Structure

AM-Imidazole-PA-Boc Chemical Structure

CAS No. : 2357108-99-5

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25 mg USD 960 In-stock
50 mg USD 1550 In-stock
100 mg USD 2500 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

AM-Imidazole-PA-Boc Related Antibodies

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Description

AM-Imidazole-PA-Boc is an alkyl chain-based PROTAC linker can be used in the synthesis of PROTAC IRAK4 degrader-1 (HY-129966)[1].

IC50 & Target

Alkyl-Chain

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AM-Imidazole-PA-Boc Related Antibodies
Molecular Weight

254.33

Formula

C12H22N4O2
CAS No.
Appearance

Oil

Color

Off-white to gray

SMILES

NCC1=CN(CCCNC(OC(C)(C)C)=O)C=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (393.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9319 mL 19.6595 mL 39.3190 mL
5 mM 0.7864 mL 3.9319 mL 7.8638 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.22%

COA (243 KB) HNMR (179 KB) LCMS (75 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.9319 mL 19.6595 mL 39.3190 mL 98.2975 mL
5 mM 0.7864 mL 3.9319 mL 7.8638 mL 19.6595 mL
10 mM 0.3932 mL 1.9659 mL 3.9319 mL 9.8297 mL
15 mM 0.2621 mL 1.3106 mL 2.6213 mL 6.5532 mL
20 mM 0.1966 mL 0.9830 mL 1.9659 mL 4.9149 mL
25 mM 0.1573 mL 0.7864 mL 1.5728 mL 3.9319 mL
30 mM 0.1311 mL 0.6553 mL 1.3106 mL 3.2766 mL
40 mM 0.0983 mL 0.4915 mL 0.9830 mL 2.4574 mL
50 mM 0.0786 mL 0.3932 mL 0.7864 mL 1.9659 mL
60 mM 0.0655 mL 0.3277 mL 0.6553 mL 1.6383 mL
80 mM 0.0491 mL 0.2457 mL 0.4915 mL 1.2287 mL
100 mM 0.0393 mL 0.1966 mL 0.3932 mL 0.9830 mL
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AM-Imidazole-PA-Boc Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AM-Imidazole-PA-Boc2357108-99-5PROTAC LinkersInhibitorinhibitorinhibit

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