2. Signaling Pathways
  3. Immunology/Inflammation
  4. IRAK
  5. IRAK Degrader

IRAK Degrader

IRAK Isoform Comparison

IRAK Degraders (3):

Cat. No. Product Name Effect Purity
  • HY-153188
    JNJ-1013
    		Degrader 99.80%
    JNJ-1013 is a potent and selective IRAK1 degrader with an IC50s of 72, 443, 1071 nM for IRAK1, IRAK4, VHL FP respectively. JNJ-1013 induces Apoptosis.html" class="link-product" target="_blank">Apoptosis and increases the expression of cleavaged PARP. JNJ-1013 decreases the expression IRAK1, p-IKBα, pSTAT3(Tyr705).
  • HY-148290
    KTX-951
    		Degrader 98.03%
    KTX-951 is a PROTAC targeting IRAK4 degradation (DC50=18 nM). KTX-951 (10 mg/kg) shows the oral bioavailability (F%) of 22% in a rat model. KTX-951 has good anticancer potential.
  • HY-153368
    IRAK degrader-1
    		Degrader
    IRAK degrader-1 (example I-3) is a potent IRAK degrader.