PROTAC IRAK4 degrader-3
Based on 1 Customer Validation
PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau.
(Pink: IRAK4 ligand (HY-19836); Blue: VHL ligand (HY-170861); Black: linker).
For research use only. We do not sell to patients.
- Purity: 98.24%
- CAS No.: 2374122-43-5
- Formula: C57H68FN11O8S
- Molecular Weight:1086.28
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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IRAK4 |
PROTAC IRAK4 degrader-3 (0.01~10 μM; 2 hours; PBMCs) mediated degradation is occurring in a proteasome dependent manner[1].
PROTAC IRAK4 degrader-3 (0.01~100 μM; 18 hours; PBMCs) is capable of completely blocking IL-6 secretion[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PBMCs
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Concentration:0.01~10 μM
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Incubation Time:2 hours
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Result:IRAK4 PROTAC-mediated degradation was occurring in a proteasome dependent manner.
Chemical Information
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CAS No. 2374122-43-5
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Appearance Solid
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Molecular Weight 1086.28
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Formula C57H68FN11O8S
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Color White to off-white
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SMILES
CC[C@H]([C@@H](C(N1)=O)F)[C@H]1COC2=NC=C(C#CCN3CCC4(CCN(C5=NC=C(C(N[C@H](C(C)(C)C)C(N6[C@H](C[C@@H](C6)O)C(NCC7=CC=C(C8=C(N=CS8)C)C=C7)=O)=O)=O)C=N5)CC4)CC3)C9=C2C=C(OC)C(C(N)=O)=C9
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL (92.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9206 mL | 4.6029 mL | 9.2057 mL | 23.0143 mL |
| 5 mM | 0.1841 mL | 0.9206 mL | 1.8411 mL | 4.6029 mL | |
| 10 mM | 0.0921 mL | 0.4603 mL | 0.9206 mL | 2.3014 mL | |
| 15 mM | 0.0614 mL | 0.3069 mL | 0.6137 mL | 1.5343 mL | |
| 20 mM | 0.0460 mL | 0.2301 mL | 0.4603 mL | 1.1507 mL | |
| 25 mM | 0.0368 mL | 0.1841 mL | 0.3682 mL | 0.9206 mL | |
| 30 mM | 0.0307 mL | 0.1534 mL | 0.3069 mL | 0.7671 mL | |
| 40 mM | 0.0230 mL | 0.1151 mL | 0.2301 mL | 0.5754 mL | |
| 50 mM | 0.0184 mL | 0.0921 mL | 0.1841 mL | 0.4603 mL | |
| 60 mM | 0.0153 mL | 0.0767 mL | 0.1534 mL | 0.3836 mL | |
| 80 mM | 0.0115 mL | 0.0575 mL | 0.1151 mL | 0.2877 mL |
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