1. Immunology/Inflammation PROTAC
  2. IRAK PROTACs
  3. PROTAC IRAK4 degrader-3

PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau.

For research use only. We do not sell to patients.

PROTAC IRAK4 degrader-3 Chemical Structure

PROTAC IRAK4 degrader-3 Chemical Structure

CAS No. : 2374122-43-5

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1 mg USD 1100 In-stock
5 mg USD 3300 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau[1].

IC50 & Target[1]

IRAK4

 

In Vitro

PROTAC IRAK4 degrader-3 (0.01~10 μM; 2 hours; PBMCs) mediated degradation is occurring in a proteasome dependent manner[1].
PROTAC IRAK4 degrader-3 (0.01~100 μM; 18 hours; PBMCs) is capable of completely blocking IL-6 secretion[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: PBMCs
Concentration: 0.01~10 μM
Incubation Time: 2 hours
Result: IRAK4 PROTAC-mediated degradation was occurring in a proteasome dependent manner.
Molecular Weight

1086.28

Formula

C57H68FN11O8S

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC[C@H]([C@@H](C(N1)=O)F)[C@H]1COC2=NC=C(C#CCN3CCC4(CCN(C5=NC=C(C(N[C@H](C(C)(C)C)C(N6[C@H](C[C@@H](C6)O)C(NCC7=CC=C(C8=C(N=CS8)C)C=C7)=O)=O)=O)C=N5)CC4)CC3)C9=C2C=C(OC)C(C(N)=O)=C9

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (92.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9206 mL 4.6029 mL 9.2057 mL
5 mM 0.1841 mL 0.9206 mL 1.8411 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9206 mL 4.6029 mL 9.2057 mL 23.0143 mL
5 mM 0.1841 mL 0.9206 mL 1.8411 mL 4.6029 mL
10 mM 0.0921 mL 0.4603 mL 0.9206 mL 2.3014 mL
15 mM 0.0614 mL 0.3069 mL 0.6137 mL 1.5343 mL
20 mM 0.0460 mL 0.2301 mL 0.4603 mL 1.1507 mL
25 mM 0.0368 mL 0.1841 mL 0.3682 mL 0.9206 mL
30 mM 0.0307 mL 0.1534 mL 0.3069 mL 0.7671 mL
40 mM 0.0230 mL 0.1151 mL 0.2301 mL 0.5754 mL
50 mM 0.0184 mL 0.0921 mL 0.1841 mL 0.4603 mL
60 mM 0.0153 mL 0.0767 mL 0.1534 mL 0.3836 mL
80 mM 0.0115 mL 0.0575 mL 0.1151 mL 0.2877 mL
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PROTAC IRAK4 degrader-3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
PROTAC IRAK4 degrader-3
Cat. No.:
HY-135382A
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