1. Immunology/Inflammation
  2. IRAK
  3. IRAK4-IN-1

IRAK4-IN-1 

Cat. No.: HY-101922 Purity: ≥99.0%
Handling Instructions

IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM.

For research use only. We do not sell to patients.

IRAK4-IN-1 Chemical Structure

IRAK4-IN-1 Chemical Structure

CAS No. : 1820787-94-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 401 In-stock
Estimated Time of Arrival: December 31
1 mg USD 180 In-stock
Estimated Time of Arrival: December 31
5 mg USD 540 In-stock
Estimated Time of Arrival: December 31
10 mg USD 900 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2640 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3960 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM.

IC50 & Target

IC50: 7 nM (IRAK4)[1]

In Vitro

The in vitro metabolic stability profiles of IRAK4-IN-1 (Compound 23) is measured, with EC50 of 2300 nM for the rat whole blood (RWB) [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Oral pharmacokinetic studies of IRAK4-IN-1 (Compound 23) show it to have high bioavailability of 73% and low plasma clearance (Clp=22 mL/min/kg) leading to a reasonable half-life of 1.3 h[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

337.42

Formula

C₁₉H₂₃N₅O

CAS No.

1820787-94-7

SMILES

N#CC1=CC2=C(N=CN=C2N[[email protected]@H]3CC[[email protected]@H](N4CCOCC4)CC3)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 14.29 mg/mL (42.35 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9637 mL 14.8183 mL 29.6367 mL
5 mM 0.5927 mL 2.9637 mL 5.9273 mL
10 mM 0.2964 mL 1.4818 mL 2.9637 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.43 mg/mL (4.24 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Animal Administration
[1]

Rats[1]
In the TLR driven in vivo model, female Lewis rats are dosed with either vehicle or IRAK4-IN-1 (Compound 23; 3, 10, 30, and 100 mg/kg; p.o.) dosed at 1 h prior to stimulation with Resiquimod, R848 (5 mg/kg, IP). At 1.5 h post R848 stimulation, blood samples are obtained from the animals and cytokine levels are measured.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

IRAK4-IN-1IRAKInterleukin-1 receptor associated kinaseIL-1R associated kinaseInhibitorinhibitorinhibit

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IRAK4-IN-1
Cat. No.:
HY-101922
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