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Cat. No.: HY-145483A

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KT-474 hydrochloride

(Synonyms: KYM-001 hydrochloride; PROTAC IRAK4 degrader-7 hydrochloride)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

KT-474 (KYM-001; PROTAC IRAK4 degrader-7) hydrochloride is an orally active PROTAC IRAK4 degrader with anti-tumor effects. KT-474 inhibits the cell cycle and induces apoptosis. KT-474 induces tumor regression in a xenograft model of MYD88-mutated ABC DLBCL.
(Pink: IRAK4 ligand (HY-145484); Blue: Cereblon ligand (HY-45512); Black: linker).

For research use only. We do not sell to patients.

Purity: ≥98.0%
CAS No.: 2751703-31-6
Formula: C₄₄H₅₀ClF₂N₁₁O₆
Molecular Weight:902.39

Storage:

Store at room temperature, keep dry and cool.

In solvent -80°C, 1 year , -20°C, 6 months

KT-474 hydrochloride Chemical Structure

CAS No.: 2751703-31-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Clinical Trial
Chemical Information
Publications (1)
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Biological Activity

Description

KT-474 (KYM-001; PROTAC IRAK4 degrader-7) hydrochloride is an orally active PROTAC IRAK4 degrader with anti-tumor effects. KT-474 inhibits the cell cycle and induces apoptosis. KT-474 induces tumor regression in a xenograft model of MYD88-mutated ABC DLBCL^[1]^[2]^[3]. (Pink: IRAK4 ligand (HY-145484); Blue: Cereblon ligand (HY-45512); Black: linker).

All PROTACs Isoforms :

All IRAK Isoforms :

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 2751703-31-6
Appearance Solid
Molecular Weight 902.39
Formula C₄₄H₅₀ClF₂N₁₁O₆
Color Light brown to brown
SMILES

O=C1N(C(CCC2=O)C(N2)=O)C3=CC=CC(C#CCOC(CC4)CCN4C[C@H]5CC[C@@](N(N=C6C(F)F)C=C6NC(C7=C(N=C(N8[C@@H](CO9)C[C@@H]9C8)C=C%10)N%10N=C7)=O)([H])CC5)=C3N1C.Cl
Synonyms

KYM-001 hydrochloride; PROTAC IRAK4 degrader-7 hydrochloride
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature, keep dry and cool

In solvent	-80°C	1 year
	-20°C	6 months

Publications (1)

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Anal Chem

Hydrogen/Deuterium Exchange for Chiral Stability Assessment in Acidic Methine-Containing Compounds. [Abstract]

2025 Dec 2;97(47):26097-26107. PMID: 41243541

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Nello Mainolfi, et al. Irak degraders and uses thereof. Patent WO2020113233A1.

[2]. Ackerman L, et al. IRAK4 degrader in hidradenitis suppurativa and atopic dermatitis: a phase 1 trial. Nat Med. 2023 Dec;29(12):3127-3136. [Content Brief]

[3]. Joseph F. Kelleher, et al. Abstract LB-272: KYM-001, a first-in-class oral IRAK4 protein degrader, induces tumor regression in xenograft models of MYD88-mutant ABC DLBCL alone and in combination with BTK inhibition. Cancer Res (2019) 79 (13_Supplement): LB-272.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

KT-474 hydrochloride

1 Cited Publications

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Biological Activity
- Description
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Publications (1)
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KT-474 hydrochloride

PROTAC Library

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

Clinical Compound Library Plus

Publications Citing Use of MedChemExpress (MCE) KT-474 hydrochloride

All PROTACs Isoforms

All IRAK Isoforms

Biological Activity

Chemical Information

Publications (1)

Purity & Documentation

References

Calculators

Help & FAQs

KT-474 hydrochloride

PROTAC Library

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

Clinical Compound Library Plus

Publications Citing Use of MedChemExpress (MCE) KT-474 hydrochloride

All PROTACs Isoforms

All IRAK Isoforms

Biological Activity

Chemical Information

Publications (1)

Purity & Documentation

References

Calculators

Help & FAQs

KT-474 hydrochloride Related Classifications

HY-145483A Related Classifications