2. PROTAC Immunology/Inflammation Apoptosis
  3. PROTACs IRAK Apoptosis
  4. KT-474 hydrochloride

KT-474 hydrochloride  (Synonyms: KYM-001 hydrochloride; PROTAC IRAK4 degrader-7 hydrochloride)

Cat. No.: HY-145483A Purity: ≥98.0%
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Handling Instructions Technical Support

KT-474 (KYM-001; PROTAC IRAK4 degrader-7) hydrochloride is an orally active PROTAC IRAK4 degrader with anti-tumor effects. KT-474 inhibits the cell cycle and induces apoptosis. KT-474 induces tumor regression in a xenograft model of MYD88-mutated ABC DLBCL. KT-474 is a click chemistry reagent, containing an alkyne group, which can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups.

For research use only. We do not sell to patients.

KT-474 hydrochloride

KT-474 hydrochloride Chemical Structure

CAS No. : 2751703-31-6

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Based on 1 publication(s) in Google Scholar

Other Forms of KT-474 hydrochloride:

KT-474 hydrochloride Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE KT-474 hydrochloride

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IRAK1 IRAK3 IRAK4

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Description

KT-474 (KYM-001; PROTAC IRAK4 degrader-7) hydrochloride is an orally active PROTAC IRAK4 degrader with anti-tumor effects. KT-474 inhibits the cell cycle and induces apoptosis. KT-474 induces tumor regression in a xenograft model of MYD88-mutated ABC DLBCL. KT-474 is a click chemistry reagent, containing an alkyne group, which can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups[1][2][3].

Clinical Trial
Molecular Weight

902.39

Formula

C44H50ClF2N11O6
CAS No.
Appearance

Solid

Color

Light brown to brown

SMILES

O=C1N(C(CCC2=O)C(N2)=O)C3=CC=CC(C#CCOC(CC4)CCN4C[C@H]5CC[C@@](N(N=C6C(F)F)C=C6NC(C7=C(N=C(N8[C@@H](CO9)C[C@@H]9C8)C=C%10)N%10N=C7)=O)([H])CC5)=C3N1C.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature, keep dry and cool

In solvent -80°C 1 year
-20°C 6 months
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (250 KB) HNMR (142 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References
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KT-474 hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KT-4742751703-31-6KYM-001PROTAC IRAK4 degrader-7KT474KT 474KYM001KYM 001PROTACsIRAKApoptosisInterleukin-1 receptor associated kinaseIL-1R associated kinaseantitumororally activeInhibitorinhibitorinhibit

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