3091132-73-6
Chemical Structure
FIP22
- CAS No.: 3091132-73-6
- Formula:C46H50N10O6
- Molecular Weight:838.95
IUPAC Name: 6-(5-cyano-1H-pyrrolo[2,3-b]pyridin-1-yl)-N-((1r,4r)-4-(9-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-3,9-diazaspiro[5.5]undecane-3-carbonyl)cyclohexyl)-4-(isopropylamino)nicotinamide
InChIKey: LTFUYINMGGXDEH-VVDHFOCHSA-N
SMILES: CC(NC1=CC(N2C=CC3=CC(C#N)=CN=C32)=NC=C1C(N[C@@H]4CC[C@H](CC4)C(N5CCC6(CC5)CCN(CC6)C7=CC=C(C8=C7)C(N(C8=O)C9C(NC(CC9)=O)=O)=O)=O)=O)C
Biological Activity: FIP22 is a potent and selective IRAK4 PROTAC degrader (HEK293T cells: DC50 = 3.2 nM; THP-1 cells: DC50 = 10.6 nM). FIP22 induces the ubiquitin-proteasome system by forming an IRAK4-FIP22-CRBN ternary complex (EC50 = 12.63 nM), thereby potently blocking IRAK4-mediated NF-κB and MAPK signaling pathways. FIP22 can be used for the study of atopic dermatitis[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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FIP22 | 98.53% | FIP22 is a potent and selective IRAK4 PROTAC degrader (HEK293T cells: DC50 = 3.2 nM; THP-1 cells: DC50 = 10.6 nM). FIP22 induces the ubiquitin-proteasome system by forming an IRAK4-FIP22-CRBN ternary complex (EC50 = 12.63 nM), thereby potently blocking IRAK4-mediated NF-κB and MAPK signaling pathways. FIP22 can be used for the study of atopic dermatitis. | ||||||||||||||||||||
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Keywords
