1. Protein Tyrosine Kinase/RTK
  2. IRAK
    FLT3
  3. CA-4948

CA-4948 

Cat. No.: HY-135317 Purity: 99.92%
Handling Instructions

CA-4948 is a potent IRAK4/FLT3 inhibtor with anti-tumor activity.

For research use only. We do not sell to patients.

CA-4948 Chemical Structure

CA-4948 Chemical Structure

CAS No. : 1801344-14-8

Size Price Stock Quantity
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3350 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

CA-4948 is a potent IRAK4/FLT3 inhibtor with anti-tumor activity[1].

IC50 & Target[1]

IRAK4

 

FLT3

 

In Vitro

CA-4948 is over 500-fold more selective for IRAK-4 compared to IRAK-1. CA-4948 reduces TNF-α, IL-1β, IL-6 and IL-8 release from TLR-Stimulated THP-1 Cells with an IC50 <250 nM. CA-4948 also has antiproliferative activity due to inhibition of receptor-type tyrosine-protein kinase FLT3[1].

In Vivo

CA-4948 shows anti-tumor activity in animal models including tumors containing MyD88 gene mutations. CA-4948 shows antileukemic activity in mouse models of FLT3 wild-type and FLT3 mutated acute myeloid leukemia (AML)[1].

Clinical Trial
Molecular Weight

491.50

Formula

C₂₄H₂₅N₇O₅

CAS No.

1801344-14-8

SMILES

O=C(C1=COC(C2=CC(C)=NC=C2)=N1)NC3=C(N4C[[email protected]](O)CC4)N=C5C(OC(N6CCOCC6)=N5)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 35.71 mg/mL (72.66 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0346 mL 10.1729 mL 20.3459 mL
5 mM 0.4069 mL 2.0346 mL 4.0692 mL
10 mM 0.2035 mL 1.0173 mL 2.0346 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.23 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.23 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

CA-4948CA4948CA 4948IRAKFLT3Interleukin-1 receptor associated kinaseIL-1R associated kinaseCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3inflammationMyd88rheumatoidarthritisTollIL-1RlymphomaInhibitorinhibitorinhibit

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Product Name:
CA-4948
Cat. No.:
HY-135317
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