1. Immunology/Inflammation
    Protein Tyrosine Kinase/RTK
  2. IRAK
    FLT3
  3. Emavusertib

Emavusertib  (Synonyms: CA-4948)

Cat. No.: HY-135317 Purity: 99.96%
COA Handling Instructions

Emavusertib (CA-4948) is a potent IRAK4/FLT3 inhibtor with anti-tumor activity.

For research use only. We do not sell to patients.

Emavusertib Chemical Structure

Emavusertib Chemical Structure

CAS No. : 1801344-14-8

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 95 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 95 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 88 In-stock
Estimated Time of Arrival: December 31
10 mg USD 110 In-stock
Estimated Time of Arrival: December 31
25 mg USD 220 In-stock
Estimated Time of Arrival: December 31
50 mg USD 400 In-stock
Estimated Time of Arrival: December 31
100 mg USD 680 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Emavusertib

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Emavusertib (CA-4948) is a potent IRAK4/FLT3 inhibtor with anti-tumor activity[1].

IC50 & Target[1]

IRAK4

 

FLT3

 

In Vitro

Emavusertib (CA-4948) is over 500-fold more selective for IRAK-4 compared to IRAK-1. Emavusertib reduces TNF-α, IL-1β, IL-6 and IL-8 release from TLR-Stimulated THP-1 Cells with an IC50 <250 nM. Emavusertib also has antiproliferative activity due to inhibition of receptor-type tyrosine-protein kinase FLT3[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Emavusertib (CA-4948) shows anti-tumor activity in animal models including tumors containing MyD88 gene mutations. Emavusertib shows antileukemic activity in mouse models of FLT3 wild-type and FLT3 mutated acute myeloid leukemia (AML)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

491.50

Formula

C24H25N7O5

CAS No.
SMILES

O=C(C1=COC(C2=CC(C)=NC=C2)=N1)NC3=C(N4C[[email protected]](O)CC4)N=C5C(OC(N6CCOCC6)=N5)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (101.73 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0346 mL 10.1729 mL 20.3459 mL
5 mM 0.4069 mL 2.0346 mL 4.0692 mL
10 mM 0.2035 mL 1.0173 mL 2.0346 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.23 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.08 mg/mL (4.23 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.23 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.96%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
Emavusertib
Cat. No.:
HY-135317
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