1. Immunology/Inflammation
    Protein Tyrosine Kinase/RTK
  2. IRAK
  3. CA-4948


Cat. No.: HY-135317
Handling Instructions

CA-4948 is a potent, selective and orally bioavailable IRAK4 kinase inhibitor with an IC50 of < 50 nM. CA-4948 can be used for the treatment of lymphoma.

For research use only. We do not sell to patients.

CA-4948 Chemical Structure

CA-4948 Chemical Structure

CAS No. : 1801344-14-8

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CA-4948 is a potent, selective and orally bioavailable IRAK4 kinase inhibitor with an IC50 of < 50 nM. CA-4948 can be used for the treatment of lymphoma[1].

IC50 & Target[1]


50 nM (IC50)

In Vivo

CA-4948 is a selective and potent IRAK4 kinase inhibitor with in vivo activity in a TLR4-induced cytokine release model. CA-4948 exhibits favorable drug metabolism and pharmacokinetic (DMPK) properties, oral bioavailability, and is well tolerated in mice. Moreover, CA-4948 exhibits dose-dependent efficacy in activated B-cell (ABC)-DLBCL MYD88-L265P xenograft tumor models using cell lines OCI-LY3 and OCI-LY10. CA-4948 exhibits the greatest efficacy in four of the five ABC-DLBCL PDX models tested as compared to GBC-DLBCL and ABC/GCB DLBCL patient-derived DLBCL tumor xenograft (PDX) models. Furthermore, CA-4948 is efficacious in ABC-DLBCL PDX tumors containing activating mutations in both TLR/IL-1R and BCR signaling pathways (MYD88 and CD79B double mutants)[2].

Molecular Weight







O=C(C1=COC(C2=CC(C)=NC=C2)=N1)NC3=C(N4C[[email protected]](O)CC4)N=C5C(OC(N6CCOCC6)=N5)=C3


Room temperature in continental US; may vary elsewhere.


Please store the product under the recommended conditions in the Certificate of Analysis.

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CA-4948CA4948CA 4948IRAKInterleukin-1 receptor associated kinaseIL-1R associated kinaseinflammationMyd88rheumatoidarthritisTollIL-1RlymphomaInhibitorinhibitorinhibit

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