1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
    Tyrosinase
  3. Glycolic acid

Glycolic acid 

Cat. No.: HY-W015967 Purity: >97.0%
Handling Instructions

Glycolic acid is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.

For research use only. We do not sell to patients.

Glycolic acid Chemical Structure

Glycolic acid Chemical Structure

CAS No. : 79-14-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
1 g USD 50 In-stock
Estimated Time of Arrival: December 31
5 g   Get quote  
10 g   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Glycolic acid is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Different concentrations of Glycolic acid (GA) or LA (300 and 500 mg/mL) are tested on the growth of mouse and human melanoma cells. Both types of cells grow well, even in the presence of 300 mg/mL of each chemical for 5 days. However, 500 mg/mL Glycolic acid inhibits the cell growth of mouse melanoma cells (41%) and humanmelanoma cells (27%), and 500 mg/mL of LA inhibits the growth of mouse melanoma cells (36%)[1].

Clinical Trial
Molecular Weight

76.05

Formula

C₂H₄O₃

CAS No.

79-14-1

SMILES

O=C(O)CO

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (1314.92 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 13.1492 mL 65.7462 mL 131.4924 mL
5 mM 2.6298 mL 13.1492 mL 26.2985 mL
10 mM 1.3149 mL 6.5746 mL 13.1492 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (32.87 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (32.87 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (32.87 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Cell Assay
[1]

HM3KO pigmented human melanoma cells and B16 mouse melanoma cells are cultured in Dulbecco’s modified Eagles medium supplemented with 10%fetal calf serum and appropriate amounts of antibiotics and fungizone were dissolved at a concentration of 100mg/mL in distilled water. These chemicals (e.g., Glycolic Acid ) are added to the cell cultures at final concentrations of 300 or 500 mg/mL every 2 days for 5 days[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: >97.0%

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Glycolic acid
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