3-O-Ethyl-L-ascorbic acid
Based on 1 Customer Validation
3-O-Ethyl-L-ascorbic acid is a stable derivative of vitamin C and a cosmetic tyrosinase inhibitor. 3-O-Ethyl-L-ascorbic acid has antioxidant, anti-aging, and skin-whitening activities. 3-O-Ethyl-L-ascorbic acid is often used in the study of cosmetic.
For research use only. We do not sell to patients.
- Purity: 99.94%
- CAS No.: 86404-04-8
- Formula: C8H12O6
- Molecular Weight:204.18
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Immunology/Inflammation Compound Library
HY-L007
-
Metabolism/Protease Compound Library
HY-L012
-
Anti-Aging Compound Library
HY-L034
-
Antioxidant Compound Library
HY-L037
-
Traditional Chinese Medicine Active Compound Library
HY-L065
-
Anti-inflammatory Traditional Chinese Medicine Active Compound Library
HY-L114
-
Metabolic Enzyme Compound Library
HY-L146
-
Radioprotector Library
HY-L178
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Bioactive Compound Library
HY-L001
-
Anti-Fibrosis Compound Library
HY-L185
-
Tibetan Medicine Compound Library
HY-L191
-
Vitamin Compound Library
HY-L197
-
High-Throughput Bioactive Compound Library
HY-L205
-
Cosmetic Ingredient Compound Library
HY-L221
-
Mongolian Medicine Compound Library
HY-L238
-
3D Diverse Fragment Library
HY-L903
Biological Activity
The cosmetic serum C-SHOT SERUM, containing 30% 3-O-Ethyl-L-ascorbic acid and 1% lactic acid, has good biocompatibility and performs excellently in photoprotection, promoting collagen synthesis, and reducing melanin content. It can prevent skin aging and pigmentation[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 86404-04-8
-
Appearance Solid
-
Molecular Weight 204.18
-
Formula C8H12O6
-
Color White to off-white
-
SMILES
O[C@@H](CO)[C@](O1)([H])C(OCC)=C(O)C1=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (489.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 100 mg/mL (489.77 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (489.77 mM); Clear solution; Need ultrasonic
Purity & Documentation
-
Data Sheet (279 KB)
-
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
-
Handling Instructions (2659 KB)
References
[1]. Wayne C Liao, et al. Antioxidant Ability and Stability Studies of 3- O-Ethyl Ascorbic Acid, a Cosmetic Tyrosinase Inhibitor. J Cosmet Sci. Jul/Aug 2018;69(4):233-243. [Content Brief]
[2]. Fotis Iliopoulos, et al. 3-O-ethyl-l-ascorbic acid: Characterisation and investigation of single solvent systems for delivery to the skin. Int J Pharm X. 2019 Jul 19;1:100025. [Content Brief]
[3]. Zerbinati N, et al. The Anti-Ageing and Whitening Potential of a Cosmetic Serum Containing 3-O-ethyl-l-ascorbic Acid. Life (Basel). 2021 Apr 29;11(5):406. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 4.8977 mL | 24.4884 mL | 48.9769 mL | 122.4422 mL |
| 5 mM | 0.9795 mL | 4.8977 mL | 9.7954 mL | 24.4884 mL | |
| 10 mM | 0.4898 mL | 2.4488 mL | 4.8977 mL | 12.2442 mL | |
| 15 mM | 0.3265 mL | 1.6326 mL | 3.2651 mL | 8.1628 mL | |
| 20 mM | 0.2449 mL | 1.2244 mL | 2.4488 mL | 6.1221 mL | |
| 25 mM | 0.1959 mL | 0.9795 mL | 1.9591 mL | 4.8977 mL | |
| 30 mM | 0.1633 mL | 0.8163 mL | 1.6326 mL | 4.0814 mL | |
| 40 mM | 0.1224 mL | 0.6122 mL | 1.2244 mL | 3.0611 mL | |
| 50 mM | 0.0980 mL | 0.4898 mL | 0.9795 mL | 2.4488 mL | |
| 60 mM | 0.0816 mL | 0.4081 mL | 0.8163 mL | 2.0407 mL | |
| 80 mM | 0.0612 mL | 0.3061 mL | 0.6122 mL | 1.5305 mL | |
| 100 mM | 0.0490 mL | 0.2449 mL | 0.4898 mL | 1.2244 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Powered by Bioz