1. Metabolic Enzyme/Protease
  2. Tyrosinase
  3. Tropolone

Tropolone 

Cat. No.: HY-N7135 Purity: >98.0%
Handling Instructions

Tropolone, a  tropone derivative with a hydroxyl group in the 2-position, is a precursor of manyazulene derivatives such as methyl 2-methylazulene-1-carboxylate. Tropolone is a potent inhibitor of mushroom tyrosinase with a IC50 of 0.4 μM, and the inhibition can be reversed by dialysis or by excess CU2+.

For research use only. We do not sell to patients.

Tropolone Chemical Structure

Tropolone Chemical Structure

CAS No. : 533-75-5

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 61 In-stock
Estimated Time of Arrival: December 31
250 mg USD 55 In-stock
Estimated Time of Arrival: December 31
500 mg   Get quote  
1 g   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Tropolone, a  tropone derivative with a hydroxyl group in the 2-position, is a precursor of manyazulene derivatives such as methyl 2-methylazulene-1-carboxylate[1]. Tropolone is a potent inhibitor of mushroom tyrosinase with a IC50 of 0.4 μM, and the inhibition can be reversed by dialysis or by excess CU2+[2].

IC50 & Target

IC50: 0.4 μM (mushroom tyrosinase)[2]

Molecular Weight

122.12

Formula

C₇H₆O₂

CAS No.

533-75-5

SMILES

O=C1C(O)=CC=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (818.87 mM)

H2O : 25 mg/mL (204.72 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 8.1887 mL 40.9433 mL 81.8867 mL
5 mM 1.6377 mL 8.1887 mL 16.3773 mL
10 mM 0.8189 mL 4.0943 mL 8.1887 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (20.47 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (20.47 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (20.47 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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The molarity calculator equation

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Keywords:

TropoloneTyrosinaseTroponeDerivativeMushroomInhibitorinhibitorinhibit

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Tropolone
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HY-N7135
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