533-75-5
533-75-5
Chemical Structure
Tropolone
- CAS No.: 533-75-5
- Formula:C7H6O2
- Molecular Weight:122.12
IUPAC Name: 2-hydroxycyclohepta-2,4,6-trien-1-one
InChIKey: MDYOLVRUBBJPFM-UHFFFAOYSA-N
SMILES: O=C1C(O)=CC=CC=C1
Biological Activity: Tropolone is a seven-membered non-benzenoid aromatic compound, which is the precursor of many Azulene derivatives. Tropolone is a potent mushroom tyrosinase inhibitor with an IC50 value of 0.4 μM. Its inhibitory effect can be achieved by dialysis or excess CU2+ Reversa. Tropolone exhibits broad anti-viral and anti-fungal activity and is synergistic upon co-treatment with nucleos(t)ide analog drugs. Tropolone is a promising candidate for research in osteosarcoma[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Tropolone | 99.96% | Tropolone is a seven-membered non-benzenoid aromatic compound, which is the precursor of many Azulene derivatives. Tropolone is a potent mushroom tyrosinase inhibitor with an IC50 value of 0.4 μM. Its inhibitory effect can be achieved by dialysis or excess CU2+ Reversa. Tropolone exhibits broad anti-viral and anti-fungal activity and is synergistic upon co-treatment with nucleos(t)ide analog drugs. Tropolone is a promising candidate for research in osteosarcoma. | ||||||||||||||||||||
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Tropolone (Standard) | 99.88% | Tropolone is a seven-membered non-benzenoid aromatic compound, which is the precursor of many Azulene derivatives. Tropolone is a potent mushroom tyrosinase inhibitor with an IC50 value of 0.4 μM. Its inhibitory effect can be achieved by dialysis or excess CU2+ Reversa. Tropolone exhibits broad anti-viral and anti-fungal activity and is synergistic upon co-treatment with nucleos(t)ide analog drugs. Tropolone is a promising candidate for research in osteosarcoma. | ||||||||||||||||||||
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2-Fluorophenol | 99.84% | 2-Fluorophenol is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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Hinokitiol (Standard) | ≥98% | Hinokitiol (Standard) is the analytical standard of Hinokitiol. This product is intended for research and analytical applications. Hinokitiol is a component of essential oils isolated from Chymacyparis obtusa, reduces Nrf2 expression, and decreases DNMT1 and UHRF1 mRNA and protein expression, with anti-infective, anti-oxidative, and anti-tumor activities. | ||||||||||||||||||||
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α-Thujaplicin | α-Thujaplicin, the isomer of Hinokitiol (HY-B2230), is an antimicrobial agent. α-Thujaplicin can be isolated from Aomori Hiba (Thujopsis dolabrata SIEB. et ZUCC. var. hondai MAKINO). α-Thujaplicin shows inhibition of Carboxypeptidase A (IC50: 32.4 μM). α-Thujaplicin shows rather strong antifungal activity against seven kinds of plant-pathogenic fungi, their MICs being in the range of 12.0-50.0 μg/mL. α-Thujaplicin shows clear antibacterial activity against Legionella pneumophila SG 1 and L. pneumophila SG 3, and their MICs are in the range of 12.5-50 μg/mL. α-Thujaplicin shows antibacterial activity against Enterococcus faecalis IFO-12965 with a MIC of 1.56 μg/mL. α-Thujaplicin shows germination inhibition toward the seed of Echinochloa utilis Ohwi et Yabuno. α-thujaplicin inhibits lymphocytic leukemia, stomach cancer, Ehrlich’s ascites carcinoma. | |||||||||||||||||||||
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Tropone | 97.80% | Tropone (Cycloheptatrienone) is a non-benzenoid aromatic natural product that acts as a membrane reverse transporter and metal chelator. Tropone disrupts the proton motive force by affecting the transmembrane proton gradient and functions as a quorum sensing signal through LuxR-type transcriptional regulators. Tropone exhibits broad-spectrum antibiotic, anticancer, algicidal, and probiotic activities. As a virulence factor toxic to rice seedlings, Tropone promotes biofilm formation in Burkholderia plantarii and induces neurotoxicity involving mitochondrial and cytoskeletal damage, increased Ca2+ influx, and oxidative stress. Tropone is used in the study of bacterial infections. | ||||||||||||||||||||
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7-Hydroxytropolone | 7-Hydroxytropolone (3-Hydroxytropolone) is an antibiotic with anti-Gram-positive bacteria, negative bacteria, yeast and fungi activity, and has the effect of inhibiting 2''-O-Adenylyltransferase. | |||||||||||||||||||||
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Phenol, potassium salt (4:1) | Phenol, potassium salt (4:1) is a metal-organic framework (MOF). | |||||||||||||||||||||
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References
- [1]. Woodson ME, et al. In vitro evaluation of tropolone absorption, metabolism, and clearance. Antiviral Res. 2023 Dec;220:105762. [Content Brief]
- [2]. Haney SL, et al. Investigation of the activity of a novel tropolone in osteosarcoma. Drug Dev Res. 2024 Feb;85(1):e22129. [Content Brief]
- [3]. Donald D Nolting,et al. Synthesis of bicyclo[5.3.0]azulene derivatives. Nat Protoc. 2009; 4(8): 1113–1117. [Content Brief]
- [4]. VardaKahn, et al.Inhibition of mushroom tyrosinase by tropolone Phytochemistry. Volume 24, Issue 5, 1985, Pages 905-908
