533-75-5
Chemical Structure
Tropolone
- CAS No.: 533-75-5
- Formula:C7H6O2
- Molecular Weight:122.12
IUPAC Name: 2-hydroxycyclohepta-2,4,6-trien-1-one
InChIKey: MDYOLVRUBBJPFM-UHFFFAOYSA-N
SMILES: O=C1C(O)=CC=CC=C1
Biological Activity: Tropolone is a seven-membered non-benzenoid aromatic compound, which is the precursor of many Azulene derivatives. Tropolone is a potent mushroom tyrosinase inhibitor with an IC50 value of 0.4 μM. Its inhibitory effect can be achieved by dialysis or excess CU2+ Reversa. Tropolone exhibits broad anti-viral and anti-fungal activity and is synergistic upon co-treatment with nucleos(t)ide analog drugs. Tropolone is a promising candidate for research in osteosarcoma[1][2][3][4].
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Tropolone | 99.96% | Tropolone is a seven-membered non-benzenoid aromatic compound, which is the precursor of many Azulene derivatives. Tropolone is a potent mushroom tyrosinase inhibitor with an IC50 value of 0.4 μM. Its inhibitory effect can be achieved by dialysis or excess CU2+ Reversa. Tropolone exhibits broad anti-viral and anti-fungal activity and is synergistic upon co-treatment with nucleos(t)ide analog drugs. Tropolone is a promising candidate for research in osteosarcoma. | ||||||||||||||||||||
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Tropolone (Standard) | ≥98% | Tropolone is a seven-membered non-benzenoid aromatic compound, which is the precursor of many Azulene derivatives. Tropolone is a potent mushroom tyrosinase inhibitor with an IC50 value of 0.4 μM. Its inhibitory effect can be achieved by dialysis or excess CU2+ Reversa. Tropolone exhibits broad anti-viral and anti-fungal activity and is synergistic upon co-treatment with nucleos(t)ide analog drugs. Tropolone is a promising candidate for research in osteosarcoma. | ||||||||||||||||||||
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References
- [1]. Woodson ME, et al. In vitro evaluation of tropolone absorption, metabolism, and clearance. Antiviral Res. 2023 Dec;220:105762. [Content Brief]
- [2]. Haney SL, et al. Investigation of the activity of a novel tropolone in osteosarcoma. Drug Dev Res. 2024 Feb;85(1):e22129. [Content Brief]
- [3]. Donald D Nolting,et al. Synthesis of bicyclo[5.3.0]azulene derivatives. Nat Protoc. 2009; 4(8): 1113–1117. [Content Brief]
- [4]. VardaKahn, et al.Inhibition of mushroom tyrosinase by tropolone Phytochemistry. Volume 24, Issue 5, 1985, Pages 905-908
