COX/5-LO-IN-2
COX/5-LO-IN-2 is a COX2, EGFR, COX1, 5-LOX, BRAF and FAK inhibitor with IC50 of 1.22 μM, 2.5 μM, 2.95 μM, 4.65 μM, 7.4 μM, 12.2 μM, respectively. COX/5-LO-IN-2 induces cell growth arrest at G2/M phase. COX/5-LO-IN-2 triggers apoptotic activity by up-regulating proapoptotic proteins p53, Bax, and caspase-7 and down-regulating anti-apoptotic protein Bcl-2. COX/5-LO-IN-2 can be used for the research of breast cancer.
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- Formule: C24H19N5O4S
- Masse moléculaire:473.50
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
Description
IC50 & Target
|
COX-2 1.22 μM (IC50) |
EGFR 2.5 μM (IC50) |
COX-1 2.95 μM (IC50) |
15-LOX 4.65 μM (IC50) |
Braf 7.4 μM (IC50) |
FAK 12.2 μM (IC50) |
Caspase-7 |
Bcl-2 |
Bax |
In Vitro
COX/5-LO-IN-2 (AS-14) (48 h) potently inhibits proliferation of PaCa-2, A-549, MCF-7, PC-3, and HT-29 human cancer cell lines with IC50 values ranging from 6.92 μM to 16.02 μM[1].
COX/5-LO-IN-2 inhibits recombinant human FAK, EGFR enzyme and BRAFV600E kinase with IC50 values of 12.2 μM, 2.5 μM, and 7.4 μM, respectively[1].
COX/5-LO-IN-2 induces G2/M phase cell cycle arrest in MCF-7 breast cancer cells at its IC50 dose of 10.27 μM[1].
COX/5-LO-IN-2 significantly induces apoptosis in MCF-7 breast cancer cells[1].
COX/5-LO-IN-2 up-regulates proapoptotic p53, Bax, and caspase-7 and down-regulates anti-apoptotic Bcl-2 in MCF-7 breast cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 473.50
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Formule C24H19N5O4S
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SMILES
O=S(C1=CC=C(N2N=C(C3=NN=C(C4=CC=C(OC)C=C4)O3)C=C2C5=CC=CC=C5)C=C1)(N)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
COX/5-LO-IN-2 Related Classifications
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