477-83-8
477-83-8
Chemical Structure
Damnacanthol
- CAS. Nr.: 477-83-8
- Formula:C16H12O5
- Molecular Weight:284.26
IUPAC Name: 3-hydroxy-2-(hydroxymethyl)-1-methoxyanthracene-9,10-dione
InChIKey: ASFZQCLAQPBWDN-UHFFFAOYSA-N
SMILES: O=C1C2=C(C=CC=C2)C(C3=CC(O)=C(CO)C(OC)=C13)=O
Biological Activity: Damnacanthol is a natural product that can be isolated from Damnacanthus major[1]. Damnacanthol has anti-15-lipoxygenase activity and can inhibit nitric oxide production in LPS-activated macrophages RAW 264.7 cells[2].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Damnacanthol | 99.86% | Damnacanthol is a natural product that can be isolated from Damnacanthus major. Damnacanthol has anti-15-lipoxygenase activity and can inhibit nitric oxide production in LPS-activated macrophages RAW 264.7 cells. | ||||||||||||||||||||
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Damnacanthal | 99.40% | Damnacanthal is an anthraquinone isolated from the root of Morinda citrifolia. Damnacanthal is a highly potent, selective inhibitor of p56lck tyrosine kinase activity. Natural Damnacanthal inhibits p56 lck autophosphorylation and phosphorylation of exogenous substrates with IC50s of 46 nM and 220 nM, respectively. Damnacanthal is a potent inducer of apoptosis with anticancer activity. Damnacanthal also has antinociceptive, anti-inflammatory effects in mice and anti-fungal activity against Candida albicans. | ||||||||||||||||||||
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Digitolutein | 94.99% | Digitolutein is a natural product that can be isolated from the stem bark and the roots of Morinda lucida Benth. Digitolutein effectively inhibits the growth of Plasmodium falciparum with an IC50 value of 12.92 μg/mL. Digitolutein can be used for the research of infection. | ||||||||||||||||||||
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Lucidin ω-ethyl ether | Lucidin ω-ethyl ether (compound 17) is an anthraquinone metabolite isolated from the root part of Prismatomeris filamentosa with some antibacterial activity against Gram-positive and Gram-negative bacteria. | |||||||||||||||||||||
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Lucidin (Standard) | ≥98% | Lucidin (Standard) is the analytical standard of Lucidin. This product is intended for research and analytical applications. Lucidin (NSC 30546) is a natural component of madder and can induce mutations in bacterial and mammalian cells. | ||||||||||||||||||||
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Lucidin-ω-Me ether | Lucidin-ω-Me ether (Compound 2) can be isolated from the roots of Knoxia valerianoides. Lucidin-ω-Me ether inhibits the advanced glycation end products (AGEs) formation in vitro(IC50: 62.79 μM). | |||||||||||||||||||||
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Purpurin-1-methylether | Purpurin-1-methylether (Compound 7) is an anthraquinone found in Galium spurium var. echinospermon Hayek. | |||||||||||||||||||||
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Rubiadin-1-methyl ether | 98.57% | Rubiadin-1-methyl ether is an orally potent NF-κB p65 inhibitor and autophagy inhibitor. Rubiadin-1-methyl ether inhibits RANKL-induced phosphorylation and nuclear translocation of p65, suppresses BECN1 transcription, blocks LC3 conversion and autophagosome formation, thereby reducing the levels of BECN1 mRNA and Beclin1 protein. Rubiadin-1-methyl ether inhibits osteoclastogenesis, cell proliferation, macrophage M2 polarization and the TGF-β1 signaling pathway, and effectively alleviates pulmonary inflammation. Rubiadin-1-methyl ether is widely used in research on osteoporosis, pulmonary fibrosis, idiopathic pulmonary fibrosis, acute lung injury and other related diseases. | ||||||||||||||||||||
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2-Hydroxy-1-methoxyanthraquinone | 99.98% | 2-Hydroxy-1-methoxyanthraquinone could be isolated from the stem bark of Morinda lucida Benth. (Rubiaceae) and possesses antibacterial activity. |
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Anthragallol-2-methyl ether | Anthragallol-2-methyl ether (compound 4) can be isolated from the fruits of Morinda citrifolia. | |||||||||||||||||||||
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Anthragallol 1,2-dimethyl ether | Anthragallol 1,2-dimethyl ether (compound 11) can be isolated from O. umbellata. Anthragallol 1,2-dimethyl ether has cytotoxicity, with IC50 values of 5.9 and 8.8 μg/ml against A549 cells and MDA-MB-231 cells, respectively. | |||||||||||||||||||||
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References
- [1]. Ayyangar N R, et al. Anthraquinone and anthrone series—XXIII: The non-identity of 1: 3: 8-trihydroxy-2-hydroxymethyl-anthraquinone with versicolorin and a synthesis of damnacanthol and damnacanthal. Tetrahedron, 1959, 6(4): 331-337.
- [2]. Dzoyem JP, et al. Inhibition of Nitric Oxide Production in LPS-Stimulated RAW 264.7 Macrophages and 15-LOX Activity by Anthraquinones from Pentas schimperi. Planta Med. 2016 Sep;82(14):1246-51. [Content Brief]
