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Chebulagic acid 

Cat. No.: HY-N1996 Purity: 99.27%
Handling Instructions

Chebulagic acid is a COX-LOX dual inhibitor isolated from the fruits of Terminalia chebula Retz, on angiogenesis.

For research use only. We do not sell to patients.

Chebulagic acid Chemical Structure

Chebulagic acid Chemical Structure

CAS No. : 23094-71-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 403 In-stock
Estimated Time of Arrival: December 31
2 mg USD 156 In-stock
Estimated Time of Arrival: December 31
5 mg USD 240 In-stock
Estimated Time of Arrival: December 31
10 mg USD 384 In-stock
Estimated Time of Arrival: December 31
25 mg USD 868 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Chebulagic acid is a COX-LOX dual inhibitor isolated from the fruits of Terminalia chebula Retz, on angiogenesis. target: COX-LOX [1] In vitro: Chebulagic acid can enhance the autophagy. Chebulagic acid exert anti-inflammatory and anti-infective effects. [1] [2] Chebulagic acid also show a protective effect against 1-methyl-4-phenylpyridinium (MPP+) - induce cytotoxicity which mimics the pathological symptom of Parkinson's disease. Chebulagic acid inhibit the LPS-induced upregulation of TNF-α and IL-1β in a dose- and time-dependent manner. Furthermore, LPS-activated MAPK signaling is inhibited by CA treatment in the EA.hy926 cells. [3]

Molecular Weight

954.66

Formula

C₄₁H₃₀O₂₇

CAS No.

23094-71-5

SMILES

OC(CC(C(O[[email protected]]([[email protected]@H](COC(C1=CC(O)=C2O)=O)O[[email protected]@H]3OC(C4=CC(O)=C(O)C(O)=C4)=O)[[email protected]](OC(C5=CC(O)=C(O)C(O)=C5C1=C2O)=O)[[email protected]]3OC6=O)=O)C(C7O)C(C6=CC(O)=C8O)=C8OC7=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (104.75 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0475 mL 5.2375 mL 10.4749 mL
5 mM 0.2095 mL 1.0475 mL 2.0950 mL
10 mM 0.1047 mL 0.5237 mL 1.0475 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.83 mg/mL (0.87 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.83 mg/mL (0.87 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.83 mg/mL (0.87 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product name:
Chebulagic acid
Cat. No.:
HY-N1996
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