1. Immunology/Inflammation
  2. NO Synthase
  3. S-Methylisothiourea sulfate

S-Methylisothiourea sulfate 

Cat. No.: HY-79457
Handling Instructions

S-Methylisothiourea sulfate is a potent, selective and competitive inhibitor of inducible nitric oxide synthase (iNOS). S-Methylisothiourea sulfate exerts beneficial effects in rodent models of septic shock.

For research use only. We do not sell to patients.

S-Methylisothiourea sulfate Chemical Structure

S-Methylisothiourea sulfate Chemical Structure

CAS No. : 867-44-7

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Description

S-Methylisothiourea sulfate is a potent, selective and competitive inhibitor of inducible nitric oxide synthase (iNOS). S-Methylisothiourea sulfate exerts beneficial effects in rodent models of septic shock[1].

IC50 & Target

iNOS[1]

In Vitro

S-Methylisothiourea sulfate is a competitive inhibitor of iNOS activity at the L-arginine site[1].
S-Methylisothiourea sulfate prevents the NO-mediated cytotoxic effect of LPS in cultured macrophages[1].
S-Methylisothiourea sulfate (100 nM-100 μM) exhibits inhibitory effects on LPS (ug/mL)-induced nitrite production in J774.2 macrophages and rat aortic vascular smooth muscle cells[1].
S-Methylisothiourea sulfate(up to 1 mM) does not inhibit the activity of xanthine oxidase, diaphorase, lactate dehydrogenase, monoamine oxidase, catalase, cytochrome P450, or superoxide dismutase[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

S-Methylisothiourea sulfate (0.01-3 mg/kg; i.v.) dose-dependently reverses the hypotension and the vascular hyporeactivity to vasoconstrictor agents caused by endotoxin LPS in anesthetized rats[1].
S-Methylisothiourea sulfate (5 mg/kg, i.p., given 2 hr after LPS, 10 mg/kg, i.p.) attenuates the rises in plasma alanine and aspartate aminotransferases, bilirubin, and creatinine and also prevents hypocalcaemia when measured 6 hr after administration of LPS[1].
S-Methylisothiourea sulfate (1 mg/kg, i.p.) improves 24-hr survival of mice treated with a high dose of LPS (60 mg/kg, i.p.)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (260-320 g)[1]
Dosage: 0.01 mg/kg, 0.1 mg/kg, 1 mg/kg, 3 mg/kg
Administration: Intravenous injection
Result: Caused a prompt restoration of the blood pressure to pre-LPS levels at 3 mg/kg dose in LPS (10 mg/kg, i.v.)-treated rats; Inhibits iNOS activity measured in homogenates of lung.
Molecular Weight

139.18

Formula

C₂H₆N₂S.₁/₂H₂O₄S

CAS No.

867-44-7

SMILES

NC(SC)=N.O=S(O)(O)=O.[1/2]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 65 mg/mL (467.02 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.1849 mL 35.9247 mL 71.8494 mL
5 mM 1.4370 mL 7.1849 mL 14.3699 mL
10 mM 0.7185 mL 3.5925 mL 7.1849 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

S-MethylisothioureaNO SynthaseNitric oxide synthasesNOSiNOSNOS bloodpressurehypotensionsepticshockcirculatoryInhibitorinhibitorinhibit

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S-Methylisothiourea sulfate
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HY-79457
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