S-Methylisothiourea sulfate
Based on 1 publication(s) in Google Scholar
S-Methylisothiourea sulfate is a potent, selective and competitive inhibitor of inducible nitric oxide synthase (iNOS). S-Methylisothiourea sulfate exerts beneficial effects in rodent models of septic shock.
For research use only. We do not sell to patients.
- Purity: 99.94%
- CAS No.: 867-44-7
- Formula: C2H6N2S.1/2H2O4S
- Molecular Weight:139.18
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) S-Methylisothiourea sulfate
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Biological Activity
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iNOS |
S-Methylisothiourea sulfate is a competitive inhibitor of iNOS activity at the L-arginine site[1].
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S-Methylisothiourea sulfate prevents the NO-mediated cytotoxic effect of LPS in cultured macrophages[1].
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S-Methylisothiourea sulfate (100 nM-100 μM) exhibits inhibitory effects on LPS (ug/mL)-induced nitrite production in J774.2 macrophages and rat aortic vascular smooth muscle cells[1].
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S-Methylisothiourea sulfate (up to 1 mM) does not inhibit the activity of xanthine oxidase, diaphorase, lactate dehydrogenase, monoamine oxidase, catalase, cytochrome P450, or superoxide dismutase[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
? S-Methylisothiourea sulfate (5 mg/kg; i.p.; given 2 hr after LPS; 10 mg/kg; i.p.) attenuates the rises in plasma alanine and aspartate aminotransferases, bilirubin, and creatinine and also prevents hypocalcaemia when measured 6 hr after administration of LPS[1].
? S-Methylisothiourea sulfate (1 mg/kg; i.p.) improves 24-hr survival of mice treated with a high dose of LPS (60 mg/kg; i.p.)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats (260-320 g)[1]
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Dosage:0.01 mg/kg, 0.1 mg/kg, 1 mg/kg, 3 mg/kg
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Administration:Intravenous injection
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Result:Caused a prompt restoration of the blood pressure to pre-LPS levels at 3 mg/kg dose in LPS (10 mg/kg, i.v.)-treated rats; Inhibited iNOS activity measured in homogenates of lung.
Chemical Information
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CAS No. 867-44-7
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Appearance Solid
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Molecular Weight 139.18
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Formula C2H6N2S.1/2H2O4S
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Color White to off-white
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SMILES
NC(SC)=N.O=S(O)(O)=O.[1/2]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
H2O : 65 mg/mL (467.02 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (359.25 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (276 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 7.1849 mL | 35.9247 mL | 71.8494 mL | 179.6235 mL |
| 5 mM | 1.4370 mL | 7.1849 mL | 14.3699 mL | 35.9247 mL | |
| 10 mM | 0.7185 mL | 3.5925 mL | 7.1849 mL | 17.9624 mL | |
| 15 mM | 0.4790 mL | 2.3950 mL | 4.7900 mL | 11.9749 mL | |
| 20 mM | 0.3592 mL | 1.7962 mL | 3.5925 mL | 8.9812 mL | |
| 25 mM | 0.2874 mL | 1.4370 mL | 2.8740 mL | 7.1849 mL | |
| 30 mM | 0.2395 mL | 1.1975 mL | 2.3950 mL | 5.9875 mL | |
| 40 mM | 0.1796 mL | 0.8981 mL | 1.7962 mL | 4.4906 mL | |
| 50 mM | 0.1437 mL | 0.7185 mL | 1.4370 mL | 3.5925 mL | |
| 60 mM | 0.1197 mL | 0.5987 mL | 1.1975 mL | 2.9937 mL | |
| 80 mM | 0.0898 mL | 0.4491 mL | 0.8981 mL | 2.2453 mL | |
| 100 mM | 0.0718 mL | 0.3592 mL | 0.7185 mL | 1.7962 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
S-Methylisothiourea sulfate Related Classifications
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