Sodium propionate-d₃ 

Sodium propionate-d₃ is the deuterium labeled Propionate sodium (HY-B1773A). Sodium propionate is an orally active short-chain fatty acid. Sodium propionate can be produced by intestinal bacteria from the metabolism of dietary fiber. Sodium propionate increases PPAR-γ, inhibits NF-κB activation, and reduces COX-2 expression and NO production. Sodium propionate also induces Apoptosis and Autophagy. Sodium propionate reduces HSV-1-induced keratitis. Sodium propionate has anticancer effects against glioblastoma. Sodium propionate exhibits neuroprotective, antioxidant, and anti-inflammatory activities. Sodium propionate can be used in the research of spinal cord injury and Alzheimer's disease^{[1][2][3][4][5][6]}.

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

99.08

C₃H₂D₃NaO₂

1210410-35-7

137-40-6

Solid

White to off-white

[2H]C([2H])([2H])CC(O[Na])=O

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

• [1]. Filippone A, et al. Sodium Propionate Contributes to Tumor Cell Growth Inhibition through PPAR-γ Signaling. Cancers (Basel). 2022 Dec 29;15(1):217.  [Content Brief]

  [2]. Filippone A, et al. The anti-inflammatory and antioxidant effects of sodium propionate. International journal of molecular sciences, 2020, 21(8): 3026.

  [3]. Filippone A, et al. Protective effect of sodium propionate in Aβ1-42-induced neurotoxicity and spinal cord trauma. Neuropharmacology. 2020 Apr;166:107977.  [Content Brief]

  [4]. Park HS, et al. Sodium propionate exerts anticancer effect in mice bearing breast cancer cell xenograft by regulating JAK2/STAT3/ROS/p38 MAPK signaling. Acta Pharmacol Sin. 2021 Aug;42(8):1311-1323.  [Content Brief]

  [5]. Sumbria D, et al. Supplementing the Diet with Sodium Propionate Suppresses the Severity of Viral Immuno-inflammatory Lesions. J Virol. 2021 Jan 28;95(4):e02056-20.  [Content Brief]

  [6]. Lang W, et al. Sodium propionate improves cognitive and memory function in mouse models of Alzheimer's disease. Neurosci Lett. 2022 Nov 20;791:136887.  [Content Brief]