1. Cell Cycle/DNA Damage
    Antibody-drug Conjugate/ADC Related
    Apoptosis
  2. Antifolate
    DNA/RNA Synthesis
    ADC Cytotoxin
    Apoptosis
  3. Methotrexate disodium

Methotrexate disodium (Synonyms: Amethopterin disodium; CL14377 disodium; WR19039 disodium)

Cat. No.: HY-14519A
Handling Instructions

Methotrexate (Amethopterin) disodium, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate disodium, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia).

For research use only. We do not sell to patients.

Methotrexate disodium Chemical Structure

Methotrexate disodium Chemical Structure

CAS No. : 7413-34-5

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Based on 8 publication(s) in Google Scholar

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Description

Methotrexate (Amethopterin) disodium, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate disodium, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia)[1][2][3].

IC50 & Target

Traditional Cytotoxic Agents

 

In Vivo

Methotrexate (Amethopterin) disodium reduces thymus and spleen indices of mice. Methotrexate disodium markedly decreases white blood cells, thymic and splenic lymphocytes at dose ≥5 mg/kg. However, there is a significant difference between the treatment plus control group and the model group (p<0.01). The combination of grape seed proanthocyanidins and Siberian ginseng eleutherosides obviously diminishes the effects of Methotrexate exposure on indices of thymus and spleens in mice[2].
Methotrexate (MTX) disodium (2 mg/kg; i.p.; once in a week for 5 weeks) is effective in Freund's complete adjuvant-induced arthritis. The combination of Methotrexate disodium (1 mg/kg; i.p.; once in a week for 5 weeks) and Curcumin (30 mg/kg and 100 mg/kg, thrice a week for 5 weeks; i.p.) shows a significant anti-arthritic action and protection from hematological toxicity[4].

Molecular Weight

498.40

Formula

C₂₀H₂₀N₈Na₂O₅

CAS No.

7413-34-5

SMILES

NC1=NC(N)=C2C(N=CC(CN(C)C3=CC=C(C(N[[email protected]@H](CCC(O[Na])=O)C(O[Na])=O)=O)C=C3)=N2)=N1

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Methotrexate disodiumAmethopterin disodiumCL14377 disodiumWR19039 disodiumAntifolateDNA/RNA SynthesisADC CytotoxinApoptosisreductaseDNAsynthesisimmunosuppressantantineoplasticrheumatoidarthritislymphoblasticleukemiaInhibitorinhibitorinhibit

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Methotrexate disodium
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HY-14519A
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