Methotrexate disodium (Standard)
Methotrexate (disodium) (Standard) is the analytical standard of Methotrexate (disodium). This product is intended for research and analytical applications. Methotrexate (Amethopterin) disodium, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate disodium, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia).
For research use only. We do not sell to patients.
- CAS No.: 7413-34-5
- Formula: C20H20N8Na2O5
- Molecular Weight:498.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Purity & Documentation
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Help & FAQs
Product Information
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 7413-34-5
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Molecular Weight 498.40
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Formula C20H20N8Na2O5
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SMILES
NC1=NC(N)=C2C(N=CC(CN(C)C3=CC=C(C(N[C@@H](CCC(O[Na])=O)C(O[Na])=O)=O)C=C3)=N2)=N1
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Synonyms
Amethopterin disodium (Standard); CL14377 disodium (Standard); WR19039 disodium (Standard)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Tian H, et al. Understanding the mechanisms of action of methotrexate: implications for the treatment of rheumatoid arthritis. Bull NYU Hosp Jt Dis. 2007;65(3):168-73. [Content Brief]
[2]. Swierkot J, et al. Methotrexate in rheumatoid arthritis. Pharmacol Rep. 2006 Jul-Aug;58(4):473-92. [Content Brief]
[3]. Swierkot J, et al. Methotrexate in rheumatoid arthritis. Pharmacol Rep. 2006 Jul-Aug;58(4):473-92.
[4]. Banji D, et al. Evaluation of the concomitant use of methotrexate and curcumin on Freund's complete adjuvant-induced arthritis and hematological indices in rats. Indian J Pharmacol. 2011;43(5):546-550. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Methotrexate disodium (Standard) Related Classifications
HY-14519AR Related Classifications
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- Methotrexate disodium (Standard)
- 7413-34-5
- Amethopterin disodium (Standard)
- CL14377 disodium (Standard)
- WR19039 disodium (Standard)
- Antifolate
- DNA/RNA Synthesis
- ADC Payloads
- Apoptosis
- Bacterial
- Reference Standards
- reductase
- DNA
- synthesis
- immunosuppressant
- antineoplastic
- rheumatoid
- arthritis
- lymphoblastic
- leukemia
- Inhibitor
- inhibitor
- inhibit