3068797-68-9
3068797-68-9
Chemical Structure
COX-1/2-IN-12
- CAS No.: 3068797-68-9
- Formula:C21H17F3N4O2S
- Molecular Weight:446.45
InChIKey: POACWTTZPHBEIF-UHFFFAOYSA-N
SMILES: CC(C1=C(C=C(N=C21)C(C=C3)=CC=C3S(N)(=O)=O)C(F)(F)F)=NN2CC4=CC=CC=C4
Biological Activity: COX-1/2-IN-12 is an orally active dual inhibitor of COX-1 and COX-2, with an IC50 of 41.6 nM against human COX-1 and an IC50 of 31.1 nM against human COX-2. COX-1/2-IN-12 induces antinociceptive activity and inhibits edema in in vivo experiments. COX-1/2-IN-12 can be used in research related to inflammation and pain[1].
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COX-1/2-IN-12 | COX-1/2-IN-12 is an orally active dual inhibitor of COX-1 and COX-2, with an IC50 of 41.6 nM against human COX-1 and an IC50 of 31.1 nM against human COX-2. COX-1/2-IN-12 induces antinociceptive activity and inhibits edema in in vivo experiments. COX-1/2-IN-12 can be used in research related to inflammation and pain. | |||||||||||||||||||||
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